肺结核患者感染产β-内酰胺酶粘质沙雷菌及其耐药性研究

Study on patients with pulmonary tuberculosis infected by β-lactamase-producing Serratia marcescens and drug resistance

目的研究肺结核患者感染产β-内酰胺酶(ESBL)粘质沙雷菌临床特点及其耐药状况。方法通过回顾性调查方法,对某医院住院肺结核患者痰液标本检测资料进行了统计分析。结果某医院自2009-2013年期间从住院结核病患者送检痰标本中共检出粘质沙雷菌132株,其中含产ESBLs菌37株,占28.0%。结核病患者感染的粘质沙雷菌对常用抗菌药物有不同程度耐药,对头孢类、氨苄西林和氨曲南耐药率均>60%。结论肺结核患者感染的粘质沙雷菌耐药严重,应根据药敏试验结果合理选用抗菌药物。

Objective To study the clinical characteristic and drug resistance of patients with pulmonary tuberculosis were infected by 13 - lactamase - producing Serratia marcescens. Methods Retrospective investigation was used to statistical a- nalysis of the sputum samples data of hospitalized patients with pulmonary tuberculosis in a hospital. Results 132 strains of Serratia marcescens were detected from the samples of sputum specimens in a hospital in the period 2009 -2013 hospitalized patients with pulmonary tuberculosis ,which included 37 strains of ESBLs producing Serratia marcescens, the detection rate was 28. 0%. Serratia marcescens of patients with pulmonary tuberculosis infected have different degrees of resistance to com- monly used antibiotics, the resistance rates to cephalosporin antibiotics, ampicillin and ammonia were all above 60% Conclusion Drug resistance of Serratia marcescens of patients with pulmonary tuberculosis infected was serious, clinicians should choose the antibiotics according to the results of drug sensitive test.