百草枯中毒药物治疗新进展

New progress in drug treatment of paraquat poisoning

百草枯（PQ）的中毒机制目前尚不十分的清楚,进入体内可引起多脏器损伤,其中氧化应激反应在PQ中毒的发病机制中占有重要地位〔1〕,而肺脏逐渐发生纤维化是患者后期死亡的主要原因〔2〕。目前针对PQ中毒的治疗方式主要有洗胃、导泻、血液净化等,尚无特效解毒药物,但近几年的研究证实一些药物对PQ中毒有一定的疗效,现将PQ中毒药物治疗的新进展综述如下。

Summary Paraquat （1,1-dimethyl-4,4-pyridine salt cationic） is currently the most widely used organic heter- ocyclic defoliant and herbicides. But it can be absorbed by the skin, respiratory tract,gastrointestinal tract into the body,leading to damage of heart, liver,lung, kidney, and other important organ. Because symptoms of paraquat poi- soning in the early stage are not typical,and the lack of specific antidote,it is the most fateful pesticide. The degree of poisoning was positively correlated with dosage. An intake greater than 40 mg/kg can lead to explosive poison- ing. An intake of 20 to 40 mg/kg cause severe poisoning. An intake less than 20 mg/kg causes mild poisoning. Mortality of acute poisoning was 50 %-80 %. Research advances of paraquat poisoning medications in the literatures of recent years are as follows.