肝细胞癌的分子靶向治疗

Molecular targeted therapy of hepatocellular carcinoma

肝细胞癌的发病是一个复杂的、多步骤的分子变化过程。分子靶向治疗药物是通过阻断肿瘤细胞的特异性信号转导通路或阻止潜在的肿瘤血管生成的靶点,抑制肿瘤细胞的分裂增殖,从而发挥抗肿瘤作用,延长患者的生存时间。但是有关疗效的预测、药物的耐药性、治疗方案的优化选择等问题需要进一步研究与探索。

The pathogenesis of hepatocellular carcinoma is a complex, multi-step process of molecular changes. Molecular targeted therapies inhibit growth and proliferation of tumor cells, activate anti-tumor effect and prolong survival time of patients through specifically blocking signal transduction of tumor cells or preventing tumor angiogenesis of potential therapeutic target. However, further studies should be performed on predicting the efficacy or drug resistance and optimization of rational treatment schedule.