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维持性血液透析患者微炎症状态与血清α-黑色素细胞刺激素相关性分析 被引量:1

Relationship between microinflammatory state and serum alpha-melanocyte stimulating hormone in patients with maintenance hemodialysis
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摘要 有研究显示,维持性血液透析患者C-反应蛋白(CRP)水平升高并且与动脉粥样硬化、透析相关低血压、贫血、心脑血管事件等并发症密切相关[1-2]。α-黑色素细胞刺激素(α-MSH)是一种由前阿皮黑素原(POMC)逐步分解而成的十三肽,对肿瘤坏死因子(TNF)、白介素-1(IL-1)、白介素-6(IL-6)、内毒素等介导的炎症反应具有良好的抑制作用[3]。
出处 《中国实用内科杂志》 CAS CSCD 北大核心 2015年第6期534-535,共2页 Chinese Journal of Practical Internal Medicine
关键词 维持性血液透析:C-反应蛋白 Α-黑色素细胞刺激素 maintenance hemodialysis C react protein alpha-melanocyte stimulating hormone
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参考文献8

  • 1Demirci MSI, Demirci C, Ozdogan 0, et al. Relations betweenmalnutrition-inflammation-atherosclerosis and volume status. Theusefulness of bioimpedance analysis in peritoneal dialysis patients [J].Nephrol Dial Transplant, 2011, 26(5):1708-1716.
  • 2Jacobs LH, van de Kerkhof JJ, Mingels AM, et al., Inflammation,overhydration and cardiac biomarkers in haemodialysis patients: alongitudinal study[j]. Nephrol Dial Transplant, 2010, 25(1): 243-248.
  • 3金亮,王百忍,鞠躬.α-黑色素细胞刺激素的神经免疫调节作用[J].生理科学进展,2000,31(1):53-56. 被引量:4
  • 4苗玉良,李金宝,田野苹,邓小明.α-黑色素细胞刺激素的炎症抑制和免疫调节作用[J].中国危重病急救医学,2003,15(1):56-58. 被引量:4
  • 5Airaghi L, Garofalo L, Cutuli MG ,et al. Plasma concentrations ofalpha-melanocyte-stimulating hormone are elevated in patients onchronic haemodialysis [j]. Nephrol Dial Transplant, 2000,15(8):1212-1216.
  • 6Grieco P, Carotenuto A, Auriemma L,et al.Novel a-MSH peptideanalogues with broad spectrum antimicrobial activity[j]. PLoS One,2013,8(4):e61614.
  • 7Masman MF, Rodriguez AM, Svetaz L,et al. Synthesis andconformational analysis of His-Phe-Arg-Trp-NH2 and analogues withntifungal properties[j]. Bioorg Med Chem, 2006,14(22):7604-7614.
  • 8Yamaoka-Tojo M, Tojo T, Shioi T, et al. Central neurotranspeptide,alpha-melanocyte-stimulating hormone (alpha-MSH) is upregulated inpatients with congestive heart failure [J]. Intern Med, 2006,45(7):429-434.

二级参考文献24

  • 1王复周,医学生理学,1992年,340页
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