梅毒患者生殖道支原体属感染的耐药性分析与临床治疗

Drug resistance analysis and clinical treatment of Mycoplasmainfection in genital tract of patients with syphilis

目的观察梅毒住院患者生殖道支原体属感染的耐药性及临床治疗,提高临床对该疾病的认识和诊治水平。方法选取2011年3月-2013年3月321例梅毒住院患者临床资料,对入选患者进行支原体属感染分析,并对其耐药性及临床治疗效果进行对比,数据均采用SPSS16.0软件进行统计分析。结果 321例梅毒住院患者中发生支原体属感染154例,感染率为47.97%,其中解脲脲支原体(Uu)感染率为25.23%、人支原体(Mh)感染率为9.34%、Uu+Mh感染率为13.40%;支原体属对多西环素和克拉霉素的耐药率最低,为0.65%,对氧氟沙星的耐药率最高为42.21%,其次是罗红霉素及左氧氟沙星,耐药率分别为33.12%及24.03%;女性梅毒合并生殖道支原体属感染患者治疗后转阴率为63.26%,明显低于男性患者的85.71%,对比差异有统计学意义(P<0.05)。结论梅毒住院患者出现生殖道支原体属感染率偏高,支原体属耐药率最低的抗菌药物分别为多西环素和克拉霉素,耐药率最高的为氧氟沙星,男性患者的支原体属治疗转阴率明显优于女性患者。

OBJECTIVE To observe drug resistance and clinical treatment of Mycoplasma infections in genital tract of patients with syphilis ,so as to better understand the disease and improve the diagnosis in clinical practice . METHODS The clinical data of 321 cases of patients with syphilis from Mar .2011 to Mar .2013 were selected . Analysis of Mycoplasma infections was conducted to the objects and the drug resistance and clinical effect were compared .The data were all analyzed by SPSS 16 .0 software .RESULTS Totally 154 cases of patients infected by Mycoplasma in the 321 cases;the infection rate was 47 .97% .UU （Uu） infection rate was 25 .23% ,Mycoplasma hominis （Mh） infection rate was 9 .34% ,Uu and Mh mixed infection rate was 13 .40% .The drug resistance rates of mycoplasma to doxycycline and clarithromycin was the lowest of 0 .65% ,but to ofloxacin was the highest of 42 .21% ,followed by roxithromycin （33 .12% ） and levofloxacin （24 .03% ） .Comparing two groups of patients found that the negative conversion ratio of female patients with syphilis combined with genital tract Mycoplasma infections after the treatment was 63 .26% ,which was significantly lower than the 85 .71% of male patients （P〈0 .05） .CONCLUSION The long‐term hospitalized patients with syphilis have high genital tract Mycoplasma infection rate .Doxycycline and clarithromycin have the lowest antibiotics resistance rates ,while ofloxacin has the highest .The negative conversion rate of mycoplasma infections of male patients was significantly better than female patients after treatments .