预防用药对控制胸部创伤患者胸腔闭式引流术后感染的影响

Effect of prophylactic medication on controlling of infections after closed thoracic drainage for chest trauma

目的：研究预防用药对控制胸部创伤后胸腔闭式引流术后感染的影响，为临床诊治提供理论依据。方法将2010年3月－2014年3月收治的300例接受胸部创伤后胸腔闭式引流术患者，随机分为试验组和对照组，每组各150例，采用相同手术方法进行胸腔闭式引流术，缝合胸腔后，试验组患者使用头孢硫脒预防胸部创伤后胸腔闭式引流术后感染，而对照组则未使用抗菌药物进行预防，对比记录两组患者感染率，数据采用SPSS19．0软件进行统计分析。结果经治疗后，试验组患者感染率为2．6％、对照组为4．0％，两组感染率比较差异无统计学意义；试验组患者胸腔引流667～691 m l、置管时间2～8 d、抗菌药物用药时间2～8 d、住院时间3～8 d；对照组患者胸腔引流629～671 m l、置管时间3～8 d、住院时间为3～8 d ，两组患者治疗结果比较，差异无统计学意义。结论抗菌药物对控制胸部创伤后胸腔闭式引流术后感染无影响，在使用头孢硫脒预防胸部创伤后胸腔闭式引流术后感染与未使用抗菌药物预防感染患者年龄、性别、发病时间、手术方法及术后治疗等差异无统计学意义，所以试验可靠性高。

OBJECTIVE To study the effect of prophylactic medication on controlling of infections after post‐trau‐matic closed thoracic drainage ,so as to provide a theoretical basis for clinical diagnosis and treatment .METHODS Totally 300 patients who received closed thoracic drainage after chest trauma during Mar .2010 to Mar .2014 were randomly selected and randomly divided into the experimental group and the control group with 150 patients in each group .Both groups received the same surgical approach for closed thoracic drainage .After suturing ,the ex‐perimental group used the antibacterial agent cefathiamidine to prevent postoperative infection while the control group did not use antibacterial agents for prophylaxis .Infection rates in two groups of patients were recorded and compared .The software SPSS19 .0 was used for statistical analysis .RESULTS The infection rate was 2 .6% in the experimental group and 4 .0% in the control group after treatment .The drainage amount ,the catheterization time ,the antibacterial medication duration and the hospitalization time were 667-691 ml ,2-8 d ,2-8 d ,and 3-8 d in the experimental group .The drainage amount ,the catheterization time ,and the hospitalization time were and 629-671 ml ,3 -8 d ,3 -8 d in the control group .There was no significance between the two groups . CONCLUSION The antibacterial agents had no effect on the control of infections after thoracic drainage for chest trauma .As there were no significant differences in age ,genders ,time of onset ,surgical techniques and postopera‐tive therapy between patients receiving cefathiamidine and those without administration of antibacterial agents for prophylaxis ,the experiment is highly reliable .