303例药品不良反应报告分析

Report Analysis of 303 Cases of Adverse Drug Reactions

目的:分析我院药品不良反应(ADR)的特点与规律,提高临床安全用药水平,促进合理用药。方法:对我院2011-2013年收集并上报至国家ADR监测中心的303例ADR报告进行分析。结果:在303例ADR报告中,男∶女为1∶1.13;60岁以上的人群占27.06%。以静脉滴注和口服给药为主,分别为224例(73.93%)和68例(22.44%)。抗菌药物ADR发生例数最多,共200例(66.01%);中药注射剂ADR 17例(5.61%)。ADR累及器官或系统以皮肤及其附件和消化系统损害为主,分别为177例(58.42%)和54例(17.82%)。结论:加强临床ADR的监测和报告工作,应减少静脉用药,合理使用抗菌药物,重视ADR与临床用药的相关性。

Objective：To analyze the characteristics and regularity of ADRs in our hospital,improve safety medication and promote the rational drug use in clinical practice.Methods：Totally 303 cases of ADR reports col-lected and reported to the National ADR Monitoring Center from 2011 to 2013 were summarized in our hospital. Results：Among the ADR reports of 303 cases,the ratio of male to female was 1∶1.13 and 27.06% of ADRs oc-curred in the people over 60 years old. Totally 224 ADR cases（73.93%）were induced by intravenous administra-tion and 68 ADR cases（22.44%）were induced by oral administration. Totally 200 ADR cases were caused by an-tibacterial drugs（66.01%）and 17 ADR cases were caused by traditional Chinese medicine injections（5.61%）. The main clinical manifestations were lesion of skin and its appendant organ（177 cases,58.42%）and digestive system injury（54 cases,17.82%）.Conclusion：It is necessary to strengthen the monitoring and reporting of clini-cal ADR work,reduce intravenous drug use,improve the rational use of anti-infective drugs,and pay more atten-tion to the relativity of ADRs and clinical medication.