孟鲁斯特治疗伴有小气道病变的慢性咳嗽患者的临床研究

Mentelukast treatment accompanied by small airway diseases in patients with chronic cough of clinical research

目的探讨孟鲁斯特治疗伴有小气道病变的慢性咳嗽患者的临床研究。方法将2013年7月至2014年7月石家庄市第三医院呼吸内科治疗的80例伴有小气道病变的慢性咳嗽患者随机分为2组，对照组采用常规对症治疗的方法，观察组在此基础上添加孟鲁斯特治疗，1个疗程后比较2组患者的临床效果、肺通气功能、症状改善时间、不良反应等。结果观察组治疗有效率为95％，对照组有效率为92．5％，观察组咳嗽症状改善时间与对照组比较差异无统计学意义（P〈O．05）；观察组治疗后的FVC、FEVl、FEV1／FVC、PEF与对照组比较差异无统计学意义（P〉0．05）；FEF25％-75％、FEF50％、FEF75％2组比较，在年龄〈40岁患者差异有统计学意义（P〈0．05），而对于≥40岁患者差异无统计学意义（P〉O．05）；2组均未见明显不良反应（P〉0．05）。结论孟鲁斯特治疗伴有小气道病变的慢性咳嗽具有显著疗效，能够明显改善患者小气道功能，尤其对于〈40岁的患者，且患者耐受性好，有积极的临床意义。

Objective To study the mentelukast treatment accompanied by small airway diseases inpatients with chronic cough of clinical research. Methods From July 2013 to July 2014,in shijiazhuang 3rd hospital respiratory medicine treatment of 80 cases with small airway diseases in patients with chronic cough were randomly divided into two groups, the control group using conventional symptomatic treatment method, the observation group based on the auxiliary mentelukast treatment, compared two groups of patients after 1 courses of clinical effect, pulmonary ventilation function, improve symptoms, adverse reactions,etc. Results Observation group treatment effective rate was 95%,no different with the 92.5% in the control group, the difference was no statistically significant （ P〉0. 05）. Observation group after treatment of FVC, FEV1, FEV1/FVC, PEF compared with the control group had no statistical significance （ P 〉0.05）. FEF25 %-75 % ,FEF50% ,FEF75%in the observation group less 40 years the comparison,difference was significant,statistically significant （ P 〈0.05）, but the observation group for 40 or more had no statistically signitheficant difference （ P 〉 0.05）. There were no obvious adverse reactions between two groups （P 〉 0.05）. Coneluslons Mentelukast treatment with small airway diseases in chronic cough has significant curative effect, can significantly improve patients with small airway function,especially for patients in age 〈40, and patient tolerance is good, have a positive clinical significance.