景天祛斑胶囊联合超声透入氢醌霜治疗黄褐斑的临床研究

Sedum freckle capsule combined with hydroquinone cream phonophoresis in the treatment of chloasma

目的：观察景天祛斑胶囊联合超声透入氢醌霜治疗黄褐斑的临床疗效。方法本研究为随机对照研究。将符合纳入标准的180例黄褐斑患者采用随机数字表法分为2组，对照组80例给予超声波透入2%氢醌乳膏；治疗组100例在对照组基础上加服景天祛斑胶囊，均连续治疗2个月。评价治疗结束时和2个月后随访时症状和皮肤损伤总积分。结果治疗结束时，治疗组治愈率为81.0%（81/100），对照组为67.5%（54/80），2组比较差异有统计学意义（χ2＝4.320，P＝0.038）。2个月后随访时，治疗组治愈率为92.0%（92/100），对照组为76.3%（61/80），2组比较差异有统计学意义（χ2＝5.538，P＝0.019）。治疗组治疗结束时、2个月后随访时皮损总积分[（1.61±0.84）分、（1.30±0.85）分比（3.48±1.02）分，t＝14.152、16.419]均较治疗前降低（P＜0.01）；对照组治疗结束时、2个月后随访时皮损总积分[（2.04±0.61）分、（2.03±0.51）分比（3.45±1.09）分，t＝10.097、10.554]均较治疗前降低（P＜0.01）。治疗组治疗结束、2个月后随访时皮损总积分下降程度较对照组显著（t值分别为3.839、6.767，P＜0.01）。结论景天祛斑胶囊联合超声波透入氢醌乳膏可有效治疗黄褐斑。

ObjectiveTo evaluate the clinical efficacy of Sedum freckle capsule combined with hydroquinone cream phonophoresis in the treatment of chloasma.MethodsA total of 180 patients with chloasma were recruited into two groups according to the random number table, 100 in the treatment group and 80 in the control group. The patients in the control group were treated with 2% hydroquinone cream phonophoresis, and those in the treatment group received 2% hydroquinone cream phonophoresis and Sedum freckle capsules, both for 2 months. The symptom and lesion score were usedto evaluate the clinical efficacy. ResultsThe cure rates were 81.00% in the treatment group and 67.50% （χ2=4.320,P=0.038） in the control group at the end of treatment, 92.0% and 76.3% （χ2=5.538,P=0.019） at 2 months follow-up. The total lesion scores at the end of treatment and at 2 months follow-up were significantly lower than before the treatment in the treatment group （1.61 ± 0.84 and 1.30 ± 0.85vs.3.48 ± 1.02;t=14.152, 16.419, allP〈0.01） and also in the control group （2.04 ± 0.61 and 2.03 ± 0.51vs.3.45 ± 1.09;t=10.097, 10.554, allP〈0.01）. The total lesion score at the end of treatment and at 2 months follow-up were significantly lower than in the treatment group was significantly decreased than the control group （t=3.839, 6.767; allP〈0.01）.ConclusionSedum freckle capsule combined with hydroquinone cream phonophoresis could effectively treat patients with chloasma.