丹参川芎嗪辅助治疗电弧烧伤的疗效分析

Salvia miltiorrhiza and ligustrazine as an adjuvant therapy in the patients with electric arc burns

目的：评价丹参川芎嗪辅助治疗电弧烧伤患者的临床疗效。方法本研究为随机对照研究。将符合纳入标准的50例电弧烧伤患者按随机数字表法分为2组各25例，对照组视全身情况进行补液、抗休克、抗感染及局部清创磨痂等治疗，治疗组在对照组基础上加用丹参川芎嗪静脉滴注，（10 ml/d，共7 d）。结果7 d时[（25.7±3.1）%比（21.3±3.0）%；t＝5.122，P＝0.000]和14 d时[（60.3±8.6）%比（53.8±10.8）%；t＝2.434，P＝0.022]治疗组创面愈合率显著高于对照组；21 d时2组创面愈合率比较，差异无统计学意义[（99.4±1.7）%比（98.7±2.7）%；t＝1.163，P＝0.265]。治疗组、对照组愈合时间分别为（18.9±2.5）d、（20.3±2.2）d，2组比较差异有统计学意义（t＝-1.216，P＝0.020）。结论采用丹参川芎嗪辅助治疗电弧烧伤可提高术后7、14 d的创面愈合率、缩短愈合时间。

ObjectiveTo evaluate the therapeutic effect of Salvia miltiorrhiza and ligustrazine as an adjuvant therapy in the patients with electric arcburns.MethodsFifty patients with electric arc burns were divided into 2 groups according to the random number table, with 25 in each group. The patients in the treatment group received intravenous infusion of 10 ml Salvia miltiorrhiza and ligustrazineinjection for 7 days in addition to the conventional therapies, and those in the control group only treated with conventional therapies.ResultsThe rates of wound healing in the treatment group were significantly improved at 7 days（25.7% ± 3.1%vs.21.3%± 3.0%;t=5.122,P=0.000） and 14 days（60.3% ± 8.6%vs.53.8% ± 10.8%;t=2.434,P=0.022） than the control group. While at 21 days, there was no significant difference between the two groups （99.4% ± 1.7%vs.98.7% ± 2.7%;t=1.163,P=0.265）. The time to wound healing in the treatment group was significantly shorter than that in the control group （18.9 ± 2.5 dvs.20.3 ± 2.2 d;t=-1.216,P=0.020）.ConclusionsSalvia miltiorrhiza and ligustrazine injections as an adjuvant therapy has a beneficial therapeuticeffect in patients with electric arc burns.