摘要
目的:探讨专项医嘱点评对我院万古霉素类药物临床合理应用的影响。方法:记录我院2013年1~6月和2014年1~6月使用了万古霉素类药物患者的全部信息,其中前者纳入专项点评前组,后者纳入专项点评后组。对2组患者的用药情况、细菌送检率、不良反应发生率、治疗效果等进行对比分析。结果:与专项点评前组比较,专项医嘱点评后组患者实验室指标检查频次明显增加,患者细菌送检率由46.74%增长至86.87%(P〈0.01);不适宜用药由120人次降至29人次;治疗有效率由54.26%增至69.70%(P〈0.05),不良反应发生率由6.52%降至1.01%(P〈0.05)。结论:专项医嘱点评显著促进了我院万古霉素类药物临床应用的合理性,但该项管理工作仍需制度化、长期化。
Objective : To investigate the effect of special prescription comment on rational use of vancomyeins in our hospital. Methods: The information of all inpatients receiving treatment of vancomycins during Jan. - Jun. 2013 (pre-comment' group) and Jan.-Jun. 2014 (post-comment' group) was collected. The situation of medication, and bacterial examination rate, adverse reaction rate, efficacy and so on were compared, respectively. Resuits: Compared with pre-comment' group, the ratio of examination indexes for patients were increased obviously. The bacterial examination rate was increased from 46.74% to 86.87% (P 〈 0.01 ). The irrational drug uses were decreased from 120 to 29. The effective rate of treatment was increased from 54.26% to 69.70% (P 〈 0.05) , while the rate of adverse drug reactions was decreased from 6.52% to 1.01% (P 〈 0.05). Conclusion: The special prescription comment can significantly improve the rational use of vancomycins in our hospital, but the management work still needs to be institutionalized and long-term oriented.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2015年第11期1316-1320,共5页
Chinese Journal of New Drugs