Survivin基因在涎腺腺样囊性癌中的表达意义

Surviving gene expression in salivary adenoid cystic carcinoma

目的研究Survivin基因在涎腺腺样囊性癌中的表达，探索其在临床诊治中的意义。方法采用免疫组化技术对病理科确诊的46例涎腺腺样囊性癌标本及20例正常涎腺标本进行Survivin基因表达的检测和分析。结果正常涎腺组织标本均无Survivin基因表达，而73．91％的涎腺腺样囊性癌组织中Survivin基因呈阳性表达，差异有统计学意义（P〈0．05）。Survivin基因表达与患者年龄、性别、肿瘤分布部位、大小无相关性（P〉0．05），而与肿瘤TNM分期、肿瘤病理类型、是否存在淋巴结转移呈正相关关系。结论Survivin基因可作为涎腺腺样囊性癌早期诊断指标，其表达强度可作为判断预后的重要指标，针对Survivin基因开展靶向治疗与其他促凋亡治疗相结合的治疗方式将是临床诊治涎腺腺样囊性癌的重要途径。

Objective To investigate the expression of Survivin in salivary adenoid cystic carci- noma（ SACC ）, in order to guide clinical diagnosis and treatment. Methods Immunohistochemical method was used to detect the expression of Survivin in 46 patients suffered with SACC and 20 normal pa- rotid gland tissues. Results Survivin was not expressed in adjacent normal parotid gland tissues, but the positive rate of Survivin in SACC was 73.91%, there was significant difference（ P 〈 0. 05 ）. The positive expression of Survivin was not associated with ages, gender, site or tumor size, but showed positive corre- lation with TNM stages, histological classification and lymph node metastasis. Conclusions Survivin gene can be used as early diagnosis index of SACC, the overexpression of Survivin suggests the bad prog- nosis in SACC; Survivin gene may be identified as a defining diagnostic marker and a potential therapeutic target in SACC.