丹红注射液治疗脑梗死患者的临床研究

Clinical Research of Dan Hong Injection for Treatment of Cerebral Infarction

目的:观察丹红注射液对脑梗死的临床疗效并探讨其作用机制。方法:脑梗死患者202例,随机分为对照组、治疗组。对照组口服肠溶阿司匹林,静脉滴注依达拉奉+甘露醇;治疗组在此基础上加用丹红注射液;测定治疗前及治疗2周(W)后一氧化氮合成酶(NOS)及超氧化物歧化酶(SOD)含量,测定血液流变学指标并动态观测局部脑血流(r CBF),记录2组病例治疗前后神经功能缺损评分并比较其疗效。结果:丹红注射液能显著增加SOD及NOS含量,提高r CBF,神经功能缺损评分明显好转,与对照组比较均有统计学意义(P<0.05)结论:丹红注射液可降低脑梗死后脂质过氧化、具有清除氧自由基、改善局部脑血流,对脑梗死有理想的疗效。

Objective：To observe the clinical effects of Dan Hong Injection on cerebral infarction and to explore its action mecha-nism.Methods：A total of 202 patients with cerebral infarction were randomly divided into control group and treatment group.Con-trol group took oral aspirin and intravenous drip in adr ＋ mannitol;the treatment group took Dan Hong Injection in addition to abovementioned treatments;after 2 weeks （W）treatment,we measured nitric oxide synthase （NOS）and superoxide dismutase （SOD）content,determined blood rheology indicators and regional cerebral blood flow （rCBF）,nerve dysfunction scoring and com-pared the curative effect.Results：Compared with that of the control group）,Dan Hong Injection could significantly increase SOD and NOS,improve rCBF and neural function defect score.Conclusion：Dan Hong Injection can decrease the lipid peroxidation after cerebral infarction,remove oxygen free radicals,improve regional cerebral blood flow,therefore have ideal efficacy on cerebral in-farction.