摘要
目的:观察丹红注射液对脑梗死的临床疗效并探讨其作用机制。方法:脑梗死患者202例,随机分为对照组、治疗组。对照组口服肠溶阿司匹林,静脉滴注依达拉奉+甘露醇;治疗组在此基础上加用丹红注射液;测定治疗前及治疗2周(W)后一氧化氮合成酶(NOS)及超氧化物歧化酶(SOD)含量,测定血液流变学指标并动态观测局部脑血流(r CBF),记录2组病例治疗前后神经功能缺损评分并比较其疗效。结果:丹红注射液能显著增加SOD及NOS含量,提高r CBF,神经功能缺损评分明显好转,与对照组比较均有统计学意义(P<0.05)结论:丹红注射液可降低脑梗死后脂质过氧化、具有清除氧自由基、改善局部脑血流,对脑梗死有理想的疗效。
Objective:To observe the clinical effects of Dan Hong Injection on cerebral infarction and to explore its action mecha-nism.Methods:A total of 202 patients with cerebral infarction were randomly divided into control group and treatment group.Con-trol group took oral aspirin and intravenous drip in adr + mannitol;the treatment group took Dan Hong Injection in addition to abovementioned treatments;after 2 weeks (W)treatment,we measured nitric oxide synthase (NOS)and superoxide dismutase (SOD)content,determined blood rheology indicators and regional cerebral blood flow (rCBF),nerve dysfunction scoring and com-pared the curative effect.Results:Compared with that of the control group),Dan Hong Injection could significantly increase SOD and NOS,improve rCBF and neural function defect score.Conclusion:Dan Hong Injection can decrease the lipid peroxidation after cerebral infarction,remove oxygen free radicals,improve regional cerebral blood flow,therefore have ideal efficacy on cerebral in-farction.
出处
《世界中医药》
CAS
2015年第4期534-536,共3页
World Chinese Medicine
关键词
丹红注射液
脑梗死
一氧化氮合成酶
超氧化物歧化酶
血液流变学
局部脑血流
Dan Hong Injection
Cerebral infarction
Nitric oxide synthase
Superoxide dismutase
Hemorheology
Regional cerebral blood flow