脑复明滴丸对血管性痴呆大鼠学习和记忆能力的影响

Effect of Naofuming Pill on of Learning and Memorizing Abilities of Rats with Vascular Dementia

目的:探讨脑复明滴丸对血管性痴呆大鼠学习记忆能力的影响。方法:采用双侧颈总动脉结扎建立血管性痴呆模型,以安理申作为阳性对照药物。60只SD大鼠随机分为假手术组、模型组、脑复明滴丸高剂量组、脑复明滴丸中剂量组、脑复明滴丸低剂量组、阳性药对照组。采用Morris水迷宫试验和跳台实验检测大鼠的学习记忆能力。结果:在Morris水迷宫实验中,脑复明滴丸可显著缩短总路程与逃避潜伏期,并且显著延长痴呆大鼠在目标象限的停留时间。在跳台实验中,脑复明滴丸能够显著缩短痴呆大鼠的潜伏期。结论:脑复明滴丸对血管性痴呆大鼠学习和记忆功能有改善作用。

Objective：To explore the effect of Naofuming pill （NFM）on abilities of learning and memorizing of rats with vascular dementia（VD）.Methods：VD model of rats was induced by ligation of bilateral common carotid arteries.Aricept was as used positive control drug.Rats were randomly divided into sham operation group,model group,NFM high dose group,NFM middle dose group,NFMlow dose group,as well as positive control group.The ability of learning and memorizing of rats were examined by Morris water maze test and step-down test.Results：In the Morris water maze test,NFM significantly shortened the total dis-tance and the escape latency,and prolonged the residence time in the target quadrant.In the diving platform experiment,com-pared with model group rats,NFMsignificantly reduced latency.Conclusion：NFMcan improve ability of learning and memoring in rats with VD.