中国5省市居民黄酒中氨基甲酸乙酯的风险评估

Risk assessment of ethyl carbamate in Chinese rice wine among population in five provinces in China

目的对中国东南地区5省市居民黄酒中氨基甲酸乙酯暴露的健康风险进行评估。方法利用2002年中国居民营养与健康状况调查5省市18岁及以上人群黄酒消费量数据,以及2010、2011年在5省市采集黄酒样品的检测结果,采用简单分布膳食暴露评估方法对人群经黄酒摄入氨基甲酸乙酯进行估计,并对造成的健康风险进行评估。结果 5省市黄酒中氨基甲酸乙酯的平均含量为0.103 mg/kg,最大值为0.498 mg/kg。18岁以上人群黄酒氨基甲酸乙酯平均暴露量为13.4 ng/kg BW,暴露限值为22 388。黄酒饮酒者氨基甲酸乙酯平均暴露量为427.8 ng/kg BW,暴露限值为701。结论 18岁及以上全部人群黄酒氨基甲酸乙酯暴露的健康风险较低,但在黄酒饮酒者中存在较高健康风险。

Objective To assess the heahh risk of exposure of ethyl carbamate from rice wine among population in five Chinese southeast provinces and municipalities. Methods The simple distribution method was introduced in dietary exposure assessment of ethyl carbamate derived from rice wine consumed by population aged 18 and above. Subsequently, their health risk assessment was conducted. The consumption data of rice wine from Chinese Nutrition and Health Survey （2002） and the ethyl carbamate concentrate data from a survey in 2010 and 2011 were adopted in dietary exposure assessment. Results The mean and maximum values of ethyl earbamate in rice wine sample were 0. 103 and 0. 498 mg/kg respectively. The average intake of ethyl carbamate and the margin of exposure （MOE） value among population aged 18 and above were 13.4 ng/kg BW per day and 22 388 respectively. In addition, the average intake of ethyl carbamate in rice wine of consumer only was 427.8 ng/kg BW per day. Therefore, the margin of exposure value was 701. Conclusion For the population aged 18 and above, the health risk caused by ethyl carbamate intake from rice wine was quite low, however, it was rather high among population who consume the rice wine in large quantities.