重复经颅磁刺激对抑郁症患者自杀的影响

The Influence of Repetitive Transcranial Magnetic Stimulation on Depression Suicide

目的:探讨重复经颅磁刺激对抑郁症患者自杀的影响。方法:本研究对我院住院并愿意接受研究的89例抑郁症自杀患者进行研究。随机分为两组,研究组40例,对照组49例,两组均给予SSRI类药物治疗,研究组在SSRI类药物治疗的基础上联合重复经颅磁刺激治疗,每周5次,2周为一个疗程,治疗4周。分别于治疗前、治疗2周、治疗4周采用汉密尔顿抑郁量表(HRSD)和自杀意念自评量表(SIOSS)对治疗效果进行评分。结果:两组治疗前HRSD评分及SIOSS评分无显著性差异,治疗后两组的评分均有不同程度的降低,但研究组更显著(P<0.05);研究组在治疗2周后即显效,与对照组比较有显著性差异(χ2=6.059,P<0.05);治疗4周后研究组的有效率明显高于对照组(χ2=18.460,P<0.05)。结论:重复经颅磁刺激能缩短起效时间,改善抑郁症患者的临床症状,主要体现在睡眠、认知障碍、躯体化症状、迟缓及绝望感,并且能降低抑郁症患者的自杀风险。

Objective：To explore the influence of repetitive transcranial magnetic stimulation on de- pression suicide. Methods：89 depressions suicide were willing to accept the study. We randomly divided them into two groups ,40 patients were in study group and 49 patients were in the control group, the two groups were both given SSRI treatment which based on SSRI combined with repetitive transcranial mag- netic stimulation treatment,5 times a week ,2 weeks for a course of treatment, treatment for 4 weeks. All patients were measured with HRSD and SIOSS to assess the therapeutic effect before treatment, treatment for 2 weeks ,4 weeks. Results： HRSD and SIOSS had no significant differences between the two groups be- fore treatment （ P 〉 0.05 ）, scores of HRSD and SIOSS decreased in both groups after treatment, however, the study group decreased significantly （P 〈 0.05 ） ; After 2 weeks, the treatment in the study group was effective, which had a significant difference compared with the control group （ X^2 = 6. 059, P 〈 0.05 ） ; After 4 weeks treatment, the efficiency of study group was significantly higher than that of the control group （ X^2 = 18. 460, P 〈 0.05 ）. Conclusion： Repetitive transcranial magnetic stimulation can short the onset time and improve the clinical symptoms of depression, which mainly reflect in cognitive disturbance, sleep, somatization, retardation and hopelessness, so it can reduce the risk of depression suicide.