乳腺非霍奇金淋巴瘤误诊为乳腺癌临床病理分析

Clinicopathological analyses of breast non-Hodgkin's lymphoma misdiagnosed as breast cancer

目的:探讨乳腺非霍奇金淋巴瘤的临床及病理特点,减少误诊误治。方法:对所获军事医学科学院附属医院病理科诊断为乳腺非霍奇金淋巴瘤1例病例的临床及病理资料进行回顾性分析。结果:本例主因发现双乳肿物一月余,行抗炎治疗后肿物无明显变化,临床以双乳肿物,初步考虑"乳腺癌"收入院。入院后行PET-CT及腹部CT发现:除了双乳高代谢肿物外,还可见腹盆腔、右肾、右侧髂肌及左侧肛提肌外旁等多发占位,病理穿刺结果开始考虑为乳腺低分化癌并多发转移,后经过免疫组织化学证实为乳腺非霍奇金T细胞性淋巴瘤,类型为ALK阴性的间变性大细胞淋巴瘤。结论:乳腺非霍奇金淋巴瘤临床及病理类型少见,易误诊为低分化癌,应加强对乳腺淋巴瘤的临床及病理学特征的认识并仔细分析病情,以避免或减少误诊误治。

Objective：To explore the characteristics of clinicopathology, so as to reduce misdiagnosis rate. Methods：A case of breast non-hodgkin’s lymphoma in Affliated Hospital of Academy of Military Medical Sciences clinicopathology data was retrospectively analyzed. Results：hTe patient was admitted for bilateral breast neoplasm for one month and mass did not change signiifcantly atfer anti-inlfammatory treatment, so as to initially consider“breast cancer”. hTe patient was found that it was visible placeholder among abdominal pelvic, right kidney, right iliac muscle and the letf anal mention muscle by PET-CT and the abdominal CT, except bilateral breast high metabolism neoplasm. Pathological biopsy results began to consider breast poorly differentiated carcinoma with multiple transfer, and conifrmed that breast non-hodgkin’s T cell lymphoma by immunohistochemistry, and the type was ALK negative anaplastic large cell lymphoma. Conclusion：Clinical and pathological type of breast non-Hodgkin’s lymphoma was rare, which can be misdiagnosed poorly differentiated carcinoma, easily, so as to strengthen the clinical and pathological characteristics of breast lymphoma awareness and careful analysis of the condition in order to avoid or reduce misdiagnosis.