摘要
目的观察乳腺结构紊乱组织中P21活化蛋白激酶4(P21 activated protein kinases 4,PAK4)的表达及其与影像诊断的相关性,探讨对乳腺结构紊乱患者手术治疗的指导价值。方法回顾性分析了2012年1月至2013年10月150例接受手术治疗的女性乳腺疾病患者资料。采用HE染色和PAK4免疫组化染色重新检测患者的组织标本。结果乳腺非增生性病变组(n=50)、乳腺增生症组(n=50)、乳腺癌组(n=50)中的PAK4表达阳性率依次升高,且三组两两比较的PAK4表达差异均具有统计学意义(均P<0.05)。在乳腺癌组中,PAK4表达与钼靶X线和超声的早期诊断结果呈正相关性(均P<0.05)。结论 PAK4表达不但在乳腺非增生性病变、乳腺增生症病变和乳腺癌中依次升高,且与乳腺癌术前影像学诊断结果呈正相关,或可用于指导乳腺结构紊乱疾病的手术治疗。
Objective To observe the PAK4 （P21 activated protein kinases 4） expression in structural disorder of mammary gland, and to investigate the correlation between PAK4 and diagnostic imaging to guide surgery. Method 150 female patients with breast disease who had surgeries during 2012 to 2013 were retrospectively analyzed. HE staining and PAK4 immunohistochemical staining were used to investigate the structure of mammary gland in the par-affin-embedded samples. Result The incidence of positive PAK4 expression increased in non-hyperplasia group （n =50）, hyperplasia group （n = 50） and the breast cancer group （n = 50）, and the differences between groups were signif-icant （all P 〈 0.05）. PAK4 expression in breast cancer group was positively correlated with early diagnostic results of mammography and ultrasonography. Conclusion The PAK4 expression increased in non-hyperplasia/hyperplasia of mammary gland, and breast cancer, besides, the PAK4 expression was positively correlated with preoperative imaging diagnosis results, and might be an indicator for breast surgeries for structural disorder of mammary gland disease.
出处
《癌症进展》
2015年第3期298-301,305,共5页
Oncology Progress
