中药复方干预激素性股骨头坏死的实验研究

Experimental Study on Traditional Chinese Medicine Intervention on Femoral Head Necrosis

目的:探讨激素性股骨头坏死游离脂肪酸的代谢变化及中药复方的预防干预作用。方法:应用高效液相色谱检测动物模型血浆和股骨头组织中的游离脂肪酸。结果:在3周和5周的时间点上,动物血浆和股骨头组织中的游离脂肪酸代谢出现紊乱。结论:游离脂肪酸代谢异常是激素性股骨头坏死的重要病理基础;中药可以早期预防干预激素性股骨头坏死。

Objective：To investigate the free fatty acid metabolic changes in animal model of femoral head necrosis ,and identify the preventive effect of Chinese herbal compound to this disease .Methods：The free fatty acid contents in plasma and femoral head tissues of animal models were detected with high performance liquid chromatography （ HPLC ） .Results：On the third and fifth week,the animal plasma and tissues of the femoral head appeared free fatty acid metabolism disorder .Conclusion：Abnormal me-tabolism of free fatty acid is an important pathological basis of femoral head necrosis ;and traditional Chinese medicine can prevent early stage of femoral head necrosis .