肾康注射液联合川芎素治疗高血压肾病的效果及其对肾功能与炎性因子的影响

Curative efficacy of Shenkang injection in combination with sodium ferulate and its effects on renal function and inflammatory factors in patients with hypertensive nephropathy

目的探讨肾康注射液联合川芎素治疗高血压肾病的效果及对患者肾功能与炎性因子的影响。方法将90例符合纳入标准的高血压肾病患者随机分为对照组与观察组,每组各45例。所有患者给予抗高血压等常规治疗,对照组在常规治疗基础上给予肾康注射液治疗,观察组患者在对照组基础上联合使用川芎素治疗。4周后观察比较两组患者临床疗效,肾功能、炎性因子水平及不良反应发生情况。结果观察组患者治疗总有效率为93.3%(42/45),对照组为77.8%(35/45),两组比较差异具有显著性(P<0.05)。治疗前两组患者血肌酐(Scr)、尿素氮(BUN)和尿蛋白水平比较差异均无显著性(P>0.05)。治疗后两组患者上述指标水平较治疗前均有不同程度下降,差异具有显著性(P<0.05),观察组下降较对照组更显著(P<0.05)。治疗前两组患者肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-6和C反应蛋白(CRP)水平比较差异无显著性(P>0.05),治疗后两组患者上述指标水平较治疗前均有不同程度下降,差异具有显著性(P<0.05),观察组下降较对照组更显著(P<0.05)。治疗过程中,两组患者均未发生明显的不良反应。结论肾康注射液联合川芎素是高血压肾病的一种有效治疗方案,可以提高治疗有效率,改善患者肾功能,减轻炎性反应,且不良反应少,值得临床进一步研究。

Objective To investigate the clinical effect of Shenkang injection in combination with sodium ferulate and its effects on renal function and inlfammatory factors in patients with hypertensive nephropathy. Method 90 cases of hypertensive nephropathy according with the inclusion critera were randomly divided into two groups equally. Besides conventional treatments, control group were treated with Shenkang injection and observation group were treated with Shenkang injection and sodium ferulate. After 4 weeks, the curative efficacy, indices reflecting renal function and inflammatory factors were observed and compared. Result The total effective rate of observation group was 93.3% （42/45）, control group was 77.8% （35/45）, the difference between the two groups was signiifcant （P 〈 0.05）. The two groups of patients before treatment serum creatinine （Scr）, blood urea nitrogen （BUN） and urine protein levels had no signiifcant difference （P〉0.05）. After treatment, the above indicators levels of the two groups were decreased compared with befor treatment （P 〈 0.05）, observation group decreased more signiifcantly than control group （P 〈 0.05）. The two groups of patients before treatment, tumor necrosis factor-α（TNF-α）, interleukin （IL）-6 and C-reactive protein （CRP） levels had no signiifcant difference （P〉0.05）. After treatment, the above indicators levels of the two groups were decreased compared with befor treatment （P〈0.05）, observation group decreased more signiifcantly than control group （P 〈 0.05）. In the course of treatment, the two groups of patients were not found obvious adverse reaction. Conclusion Combined treatment of Shenkang injection and sodium ferulate for hypertensive nephropathy is effective, which could increase the therapeutic efifcacy, signiifcantly improverenal function, alleviate inlfammatory reaction and with little adverse reactions.