摘要
A series of novel homochiral β-oligopeptides bearing aryl side chains was designed and synthesized from （S）-β-phenyl-β-amino acid derivatives by solution-phase methods. By means of circular dichroism（CD）, Fourier- transform infrared spectrometry（FTIR）, powder X-ray diffraction analysis（XRD） and density functional theory（DFT） calculations, we suggest that dipeptide P-2 and tripeptide P-3 adopt random coil-like conformations, pentapeptide P-5 and hexapeptide P-6 adopt stable 12-helix conformations in both solution and solid-state. Meanwhile, tetrapeptide P-4 adopt random coil-like conformation in solution and adopt 12-helix conformation in solid state.
A series of novel homochiral β-oligopeptides bearing aryl side chains was designed and synthesized from （S）-β-phenyl-β-amino acid derivatives by solution-phase methods. By means of circular dichroism（CD）, Fourier- transform infrared spectrometry（FTIR）, powder X-ray diffraction analysis（XRD） and density functional theory（DFT） calculations, we suggest that dipeptide P-2 and tripeptide P-3 adopt random coil-like conformations, pentapeptide P-5 and hexapeptide P-6 adopt stable 12-helix conformations in both solution and solid-state. Meanwhile, tetrapeptide P-4 adopt random coil-like conformation in solution and adopt 12-helix conformation in solid state.
基金
the National Natural Science Foundation of China（No.21172217）.
