脂肪细胞因子chemerin与动脉粥样硬化性脑梗死的关系研究

The correlation research between adipocytokines chemerin and atherosclerosis cerebral infarction

目的探讨血浆脂肪细胞因子chemerin水平与动脉粥样硬化性脑梗死的关系。方法随机选取我院2012年6月~2013年6月脑梗死急性期患者154例,根据斑块的回声特征分为无斑块组（A1组）52例、稳定型斑块组（A2组）54例和不稳定型斑块组（A3组）48例。另选检查无动脉粥样硬化性脑梗死的健康者50例为对照组（B组）。酶联免疫吸附试验（ELISA）测定各组血浆chemerin水平,分析血浆chemerin与动脉粥样硬化性脑梗死的关系。结果 （1）无斑块组（A1组）、稳定型斑块组（A2组）血浆Chemerin水平与对照组（B组）无显著性差异（P〉0.05）;不稳定型斑块组（A3组）血浆Chemerin水平与对照组（B组）差别有统计学意义（P〈0.05）;（2）血浆脂肪细胞因子Chemerin是不稳定型动脉粥样硬化性脑梗死的危险因子（OR〉1）。结论脂肪细胞因子Chemerin是不稳定型动脉粥样硬化性脑梗死的危险因素。

Objective To investigate the correlation between the levels of adipocytokines chemerin and cartiod ath- erosclerosis. Methods 154 patients who have had been in our hospital for the treatment of acute cerebral infarction be- tween Jun 2012 and Jun 2013 are were randomly selected to participate in this study. According to the echo features of ath- erosclerotic plaque, all the patients are were divided into 3 groups：no plaque group （group A1 , with 52 cases） ,stable plaque group（ group A2 ,with 54 cases） and unstable plaque group（ group A3 ,with 48 cases）. 50 healthy controls with no cerebro- vascular disease were enrolled in this study as the control group（ group B）. The serum chemerin levels of all groups of indi- vidals were determined by ELISA to analysis the relationship between the levels of chemerin and cartiod atherosclerosis. Results （ 1 ） The diffrences of the levels of chemerin between no plaque group （ group A1 ） and the control group（ group B） made no sence（P 〉 0.05 ）. So do that between stable plaque group （group Az ） and the control group （group B）（ P 〉 0.05）. Neverthless, chemerin＇ s levels in unstable plaque group（ group A3 ） were sensiblely higher than that of the control group （ group B ） （ P 〈 0.05 ）. （ 2 ） Chemerin was a risk factor to unstable atherosclerotic cerebral infarction （ OR 〉 1 ）. Con- clusion Chemerin was a risk factor to unstable atherosclerotic cerebral infarction.