血清腺苷水平对双相障碍患者疾病转归的影响

Influences of serum adenosine levels on the outcomes of bipolar disorder patient

目的：探讨血清腺苷水平对双相障碍患者疾病转归的影响。方法将40例首发双相障碍患者设为研究组，抽取40名健康职工设为对照组。研究组予以情感稳定剂治疗，观察4周，采用临床疗效总评量表评定临床疗效。研究组于治疗前及治疗4周末检测血清腺苷水平的变化，对照组于入组时检测血清腺苷水平，对两组检测结果进行对比分析。结果研究组治疗4周末病情显著好转，血清腺苷水平较治疗前显著升高（P＜0．01），但治疗前及治疗4周末血清腺苷水平均显著低于对照组（ P＜0．05或0．01）。结论腺苷可能参与了双相障碍的发病过程，可能是治疗该病的一个潜在的作用靶点。

Objective To explore the influences of serum adenosine levels on the outcomes of bipolar disor‐der （BD） patient .Methods Forty first‐episode BD patients were assigned to research group and 40 healthy employees to control group .Research group was treated with mood stabilizer for 4 weeks ,effica‐cies were assessed with the Clinical Global Impression （CGI） .Changes of serum adenosine levels before and at the end of the 4th week in research group and serum adenosine levels at enrolment in control group were detected and detection results of two groups compared .Results Research group improved signifi‐cantly at the end of the 4th week ,serum adenosine levels increased more significantly compared with pre‐treatment in research group （P〈0 .01） ,but those at enrolment and the end of the 4th week were signifi‐cantly lower compared with control group （P〈0 .05 or 0 .01） .Conclusion Adenosine is likely to partici‐pate in the pathogenic process of bipolar disorder and may be a potential therapeutic target of bipolar disor‐der .