具有近红外荧光的二氧化钛纳米粒的载药与体外释放

Drug Loading and Release of Titanium Dioxide Nanoparticles with Near-infrared Light

目的：制备具有近红外荧光的纳米二氧化钛（TiO2）,并考察纳米粒的载药及体外释放性能。方法通过水热法合成掺杂钐的 TiO2（Sm-TiO2）,采用透射电镜（TEM）对其进行表征,测定其荧光光谱,并考察对多柔比星（DOX）的载药量及体外释放曲线。结果所制备的纳米粒分散均匀,外观呈梭状,长度100-200 nm,发射波长640-670 nm,在水中的载药量达11.5%,体外释放具有 pH 敏感性。结论所制备 Sm-TiO2有良好的近红外荧光发光效果、较高的载药量及可控的体外释放,可以作为新型药物载体深入研究。

Objective To prepare titanium dioxide （TiO2 ） nanoparticles with good near-infrared light and study the loading and release of doxorubicin. Methods The Sm doped TiO2 nanoparticles （Sm-TiO2 ） were synthesized using a modified solvothermal reaction and then observed with transmission electron microscope. The fluorescence spectrum, doxorubicin loading capacity and release profile were also determined. Results The obtained Sm-TiO2 nanoparticles with the length from 100-200 nm were fusiform and well dispersed. The emission wavelength was 640-670 nm. The drug loading capacity in water was 11. 5% . DOX in vitro was pH sensitive to release. Conclusion Sm-TiO2 nanoparticles have good near-infrared light, high drug loading capacity and controllable drug release are obtained and should be studied further more as a novel carrier.