培哚普利和左旋氨氯地平治疗原发性高血压合并左室肥厚的疗效对比被引量：4

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摘要目的探讨培哚普利和左旋氨氯地平治疗原发性高血压(EH)合并左室肥厚(LVH)患者的临床疗效。方法将76例EH伴LVH患者随机分为两组(平均年龄63岁),对照组38例,治疗组38例。治疗组给予培哚普利[雅施达,施维雅(天津)制药有限公司]4mg^8mg,1次/日,早饭前口服;对照组给予苯磺酸左旋氨氯地平(施慧达,吉林天风制药公司)(2.5~5)mg,1次/日,晨起顿服;治疗24周,观察降压疗效和LVH改善情况。结果无论降压还是逆转左室肥厚方面,培哚普利均优于左旋氨氯地平(P<0.05)。治疗组降压总有效率94.8%,对照组73.8%,治疗组血压下降显著(P<0.05);治疗组左室室间隔厚度(IVST)、左室后壁厚度(LVPWT)及左室重量指数(LVM I)均较对照组改善显著(P<0.05)。结论培哚普利8mg对EH合并LVH有逆转作用,可作为治疗EH伴LVH患者的一线用药。

作者刘爱兰

机构地区山西焦煤西山煤电集团职工总医院

出处《中西医结合心脑血管病杂志》 2015年第5期623-625,共3页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

关键词原发性高血压左室肥厚培哚普利左旋氨氯地平

分类号 R544.1 [医药卫生—心血管疾病]

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