慢性阻塞性肺病患者IL-21表达及其与其他细胞因子的相关性

The level of IL-21 in serum of patients with stable COPD and its correlation with IL-6,IL-10,IL-17,IL-21,TGF-β1

目的探讨白细胞介素-21(IL-21)在慢性阻塞性肺疾病(COPD)炎性反应中的作用。方法采用辅助性T细胞1/2/17(Th1/Th2/Th17)定量抗体芯片检测稳定期COPD组、健康吸烟组、健康无吸烟组研究对象的血清IL-21、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、白细胞介素-17(IL-17)、转化生长因子-β1(TGF-β1)等细胞因子的表达水平,并同时检测各组的肺通气功能。结果稳定期COPD组患者IL-21的表达水平与IL-6、IL-10、TGF-β1呈显著正相关(r值分别为0.902、0.589、0.683,均P<0.01);与IL-17也呈正相关(r=0.313,P<0.05)。结论 IL-21在COPD的发病过程中起重要促炎作用,可作为一种有效治疗手段。

Objective Explore the role of IL-21 in COPD inflammatory reaction,improve the understanding of the pathogenesis of the disease. Methods Using the Thl/Th2/Thl7 Quantibody Array Glass Chip to test the level of IL-21, IL-6, IL-10, IL-17, TGF-β1 in serum of stable COPD group, healthy smoking group and healthy non-smoking group,and simultaneous detection of pulmonary function in each group. Results In stable group of COPD,the ex- pression of IL-21 in blood and IL-6, IL-10, TGF-β1 expression showed a significant positive correlation （r values were 0. 902,0. 589,0. 683,all P〈0.01）. IL-21 and IL-17 were positively correlated （r value of 0. 313,P〈0.05）. Conclu- sion IL-21 plays a pro-inflammatory role in the development process in COPD.