某市婚前检查阳性人群的干预价值

The effects of premarital medical examination on the prevention of birth defects in Zhongshan City

目的探讨对婚前检查阳性人群进行医学干预的价值。方法该院2012年8月至2014年7月进行婚前检查的阳性人群做相应的医学干预,并比较基线及终末干预结果。结果体检共41 372例,乙型肝炎(HBsAg)阳性5 374例;珠蛋白生成障碍筛查阳性患者3 896例,患者夫妇均为阳性154对,308例;葡萄糖-6-磷酸脱氢酶(G6PD)缺乏1 797例;致畸胎T弓形体(ToRCH)至少1项阳性223例;梅毒181例;女性甲状腺功能减退1 219例;女性糖尿病341例。对阳性人群建卡并进行跟踪及分类医学干预,未进行干预者缺陷率为20.55%,进行医学干预后为9.04%,差异有统计学意义(Z=-17.606,P=0.000)。结论对婚前检查阳性人群进行积极干预能明显降低出生缺陷发生率,对提高出生人口素质具有十分重要的临床意义。

Objective To investigate the effect of premarital medical examination on the prevention of birth de- fects. Methods The premarital disease check positive people were conducted medical intervention in our hospital from August 2012 to July 2014 and the baseline and final intervention result were compared. Results 41 372 people were accepted premarital examination. 5 374 people were HBsAg-positive, 154 couples were Mediterranean Anemia positive,1 797 people were glucose 6-phosphate dehydrogenase deficiency, 223 women were TORCH infection, 181 people were syphilis-positive, 1 219 women were hypothyroidism, and 341 women were diabetes mellitus. All positive people were tracked and given comprehensive medical intervention, the baseline incidence of birth defects was 20.55 % and medical-intervention-made incidence of birth defects was 9.04%. The differences have statistical signifi- cance （Z=-17. 606 ,P=0. 000）. Conclusion Conducting medical intervention accordingly for the premarital disease check positive people can significantly decreased the incidence of birth defects, which is significant to improve the quality of the newborn population.