肾脏相关标志物在评估妊娠高血压综合征肾损伤的研究

Clinica value of markers related kidney in assessing renal dysfunction in pregnancy induced hypertension women

目的评价胱抑素C(Cys C)、同型半胱氨酸(Hcy)、24小时尿蛋白定量(24h-UPE)、尿素(UREA)、肌酐(Scr)在妊娠高血压综合征(PIH)早期肾损伤及损伤程度应用的价值。方法检测133例PIH患者的Cys C、Hcy、24h-UPE、UREA、Scr等指标;PIH患者分为轻度、中度重度组并与30例健康妊娠者(健康对照组)作比较。结果轻度PIH组各项指标均高于健康对照组,中度、重度PIH组显著高于健康对照组、轻度PIH组,差异有统计学意义(P<0.05);Cys C和24h-UPE具有高度的相关性(r=0.780,P<0.01)。结论联合检测Cys C、Hcy、24h-UPE、UREA、Scr能更准确和客观地反映PIH患者肾脏损伤程度,有利于早期诊断与治疗。

Objective To evaluate the significance of the serum cystatin C （Cys-C） Homocysteine（Hcy）,24 h urinary protein excretion（24 h UPE）,UREA and Scr in assessing renal dysfunction in Pregnancy induced hyperten- sion（PIH） women. Methods Biochemistry was used to evaluate the level of Cys-C,Hcy,24 h UPE,UREA and Scr in 133 PIH patients （study group） who were divided into 3 groups,the low group,medium group and severe group, compared with 30 normal pregnant women（control group）. Results The concentrations of Cys-C, Hcy, 24 h-UPE, UREA and Scr were significantly higher in the low PIH group than in the control group,all in the medium PIH group and severe PIH group higher in the control group and low PIH group. Correlation analyses demonstrated significant correlations between Cys-C and 24 h-UPE in all the 133 pregnant women,r=0. 780（P〈0.01）. Conclusion Cys-C, Hcy,24 h-UPE,UREA and Scr can reflect the degree of renal function damage in patients with PIH.