尿转铁蛋白与冠状动脉粥样硬化性心脏病及冠状动脉狭窄程度关系的研究

Analysis on the relationship between urine transferring,CHD and coronary artery stenosis

目的探讨尿转铁蛋白(TRF)与冠状动脉粥样硬化性心脏病(CHD)及冠状动脉狭窄程度之间的关系。方法选取该院CHD住院患者138例(CHD组)和健康体检者108例(健康对照组)。检测2组研究对象血清高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、C反应蛋白(CRP)、肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(TnI)及TRF。对CHD的多重危险因素采用非条件Logistic回归模型进行分析。结果 CHD组患者LDL-C、CRP、CK-MB、TnI、TRF水平明显高于健康对照组,差异有统计学意义(P<0.05);CHD组HDL-C水平低于健康对照组,差异也有统计学意义(P<0.05)。Logistic回归分析显示TRF为CHD的独立危险因素,回归系数(β)为0.729,相对危险度(OR)为1.36;TRF与冠状动脉狭窄程度呈正相关(r=0.886,P<0.01)。结论 TRF是CHD的独立危险因素,其有助于对冠状动脉狭窄病变程度进行判断。

Objective To study the correlation between urine trans{errin （TRF）, coronary heart disease （CHD） and the degree of coronary artery stenosis. Methods 138 cases of the patients in the hospital were collected because of the coronary disease （CHD group）,and 108 normal persons were selected as control group （NC group）. The risk factors of cardiovascular diseases were investigated in all groups including sex,age, and history of hyperten- sion,diabetes hypercholesterolemia and smoking. The levels of serum high-density lipoprotein （HDL）, low-density lipoprotein（LDID ,C reactive protein （CRP） ,creatine kinase-MB（CK MB） ,Cardiac troponin I（cTnI） and urine trans- ferrin （TRF） were detected. The multiple risk factors of CHD were analyzed by using unconditioned Logistic regres- sion model. Results The contents of LDL,CRP,CK-MB, cTnI and TRF showed significant difference between the two groups （P〈0.01）. The multiple analysis of Logistic regression showed that TRF was an independent risk factor of CHD,regression coefficient was 0. 729 and relative risk （RR） was 1.36 （P〈0.01）. The level of TRF was correla- ted to the degree of coronary artery stenosis,r= 0. 886, P〈0.01. Conclusion TRF is an independent risk factor of CHD. The level of TRF would be used to determine the degree of coronary artery stenosis.