多囊卵巢综合征患者血清维生素D水平与抑郁症的关系

Association between serum vitamin D and depression in women with polycystic ovarian syndrome

目的 探讨多囊卵巢综合征（PCOS）患者血清维生素D水平与抑郁症的关系。方法 随机选取PCOS患者210例,测定血清25羟维生素D（25[OH]D）水平,采用贝克抑郁量表-Ⅱ（BDI）评估PCOS患者有无抑郁以及抑郁程度。结果210例PCOS患者中,76例（36.2%）合并抑郁症,合并抑郁症PCOS患者的血清25[OH]D水平显著低于未合并抑郁症的PCOS患者[11.6（8.4-14.7）μg/Lvs20.5（16.1-25.1）μg/L,P〈0.05]。血清25[OH]D与BDI评分之间呈负相关（r=-0.362,P〈0.05）。血清25[OH]D预测PCOS合并抑郁症的受试者工作特征（ROC）曲线下面积为0.908,最佳截断点为11.5μg/L。Logistic回归分析表明血清25[OH]D降低是PCOS患者合并抑郁症的独立危险因素。结论PCOS患者血清维生素D水平降低与抑郁症密切相关,补充维生素D可能为PCOS合并抑郁症的治疗提供新思路。

Objective To investigate the association between serum vitamin D and depression in women with polycystic ovarian syndrome （PCOS）.Methods A total of 210 PCOS patients were randomly enrolled in this study. Blood sample was obtained to test serum level of 25-hydroxyvitamin D （25 [OH]D）.The depression severity in the patients were evaluated using the Beck Depression Inventory-Ⅱ（BDI）.Results In all 210 PCOS women,76 patients （36.2%）suffered from depression according to BDI scores.The serum level of 25 [OH]D in PCOS women with depression was significantly lower than that in PCOS women without depression （1 1.6 [8.4-14.7]vs 20.5[1 6.1-25.1]μg/L,P 〈0.05）.There was negative correlation between the serum level of 25[OH]D and BDI scores （r =-0.362,P 〈 0.05 ）.Based on the receiver operating characteristic curve,the optimal cutoff value for serum level of 25[OH]D as an indicator for predicting depression in PCOS women was estimated to be 1 1.5 μg/L with an area under the curve of 0.908.The serum level of 25[OH]D was independently associated with depression in Logistic analysis.Conclusion Lower serum level of 25 [OH]D was associated with depression in PCOS women.Vitamin D supplementation may provide a new proposal for the treatment of depression in women with PCOS.