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多囊卵巢综合征患者血清维生素D水平与抑郁症的关系 被引量:11

Association between serum vitamin D and depression in women with polycystic ovarian syndrome
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摘要 目的 探讨多囊卵巢综合征(PCOS)患者血清维生素D水平与抑郁症的关系。方法 随机选取PCOS患者210例,测定血清25羟维生素D(25[OH]D)水平,采用贝克抑郁量表-Ⅱ(BDI)评估PCOS患者有无抑郁以及抑郁程度。结果210例PCOS患者中,76例(36.2%)合并抑郁症,合并抑郁症PCOS患者的血清25[OH]D水平显著低于未合并抑郁症的PCOS患者[11.6(8.4-14.7)μg/Lvs20.5(16.1-25.1)μg/L,P〈0.05]。血清25[OH]D与BDI评分之间呈负相关(r=-0.362,P〈0.05)。血清25[OH]D预测PCOS合并抑郁症的受试者工作特征(ROC)曲线下面积为0.908,最佳截断点为11.5μg/L。Logistic回归分析表明血清25[OH]D降低是PCOS患者合并抑郁症的独立危险因素。结论PCOS患者血清维生素D水平降低与抑郁症密切相关,补充维生素D可能为PCOS合并抑郁症的治疗提供新思路。 Objective To investigate the association between serum vitamin D and depression in women with polycystic ovarian syndrome (PCOS).Methods A total of 210 PCOS patients were randomly enrolled in this study. Blood sample was obtained to test serum level of 25-hydroxyvitamin D (25 [OH]D).The depression severity in the patients were evaluated using the Beck Depression Inventory-Ⅱ(BDI).Results In all 210 PCOS women,76 patients (36.2%)suffered from depression according to BDI scores.The serum level of 25 [OH]D in PCOS women with depression was significantly lower than that in PCOS women without depression (1 1.6 [8.4-14.7]vs 20.5[1 6.1-25.1]μg/L,P 〈0.05).There was negative correlation between the serum level of 25[OH]D and BDI scores (r =-0.362,P 〈 0.05 ).Based on the receiver operating characteristic curve,the optimal cutoff value for serum level of 25[OH]D as an indicator for predicting depression in PCOS women was estimated to be 1 1.5 μg/L with an area under the curve of 0.908.The serum level of 25[OH]D was independently associated with depression in Logistic analysis.Conclusion Lower serum level of 25 [OH]D was associated with depression in PCOS women.Vitamin D supplementation may provide a new proposal for the treatment of depression in women with PCOS.
出处 《临床荟萃》 CAS 2015年第6期649-653,共5页 Clinical Focus
基金 国家自然科学基金资助项目(81300687)
关键词 多囊卵巢综合征 抑郁症 维生素D polycystic ovarian syndrome depressive disorder vitamin D
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