干扰素抗病毒治疗对血糖的影响

Clinical observation on effect of interferon antiviral treatment on blood glucose

目的了解干扰素抗病毒治疗对血糖的影响。方法收集173例慢性病毒性肝炎患者给予干扰素抗病毒治疗,在治疗0周,4周,48周分别测定空腹血糖(FPG)及胰岛素(FINS),并计算稳态模型胰岛素抵抗指数(HOMA-IR)。结果治疗4周时FPG有下降趋势,但与治疗前比较差异无统计学意义,HOMA-IR较治疗前有所下降(P<0.05);治疗48周后空腹血糖及HOMA-IR较治疗前升高(P<0.05)。结论干扰素治疗早期可能出现胰岛素抵抗的改善,但随着治疗时间延长可能加重胰岛素抵抗,引起血糖升高。

Objective To understand the effect of antiviral therapy on blood glucose of interferon.Methods Collection of 1 73 patients with chronic viral hepatitis were given interferon antiviral therapy in the treatment of 0 week, 4 weeks and 48 weeks respectively for determination of fasting blood glucose （FPG）and insulin （FINS）,and the homeostasis model assessment insulin resistance index （HOMA-IR）was calculated.Results After four weeks of treatment,FPG decreased,but compared with before treatment,the difference was not statistically significant,HOMA-IR decreased compared with before treatment （P 〈 0.05 ）;after 48 weeks of treatment,FPG and HOMA - IR improved （P 〈0.05）.Conclusion Early use of interferon treatment appears to improve insulin resistance,but with the treatment time it may worsen insulin resistance,causing rise in blood sugar.