子痫前期患者抗磷脂抗体水平变化及与妊娠结局的相关性研究被引量：2

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摘要目的本研究采用病例对照,分析抗心磷脂抗体及抗β 2-GPI抗体的滴度值与妊娠不良结局的相关性,探讨抗磷脂抗体在妊娠高血压患者发病中的作用.方法选择2012年10月至2013年9月在我院产科住院分娩的妊娠期高血压患者60例作为研究组,其中轻度子痫前期患者30例为研究Ⅰ组,重度子痫前期患者30例为研究Ⅱ组,并选择同期住院分娩的正常产妇30例作为对照组.收集研究组及对照组的血液标本,用ELISA法检测子痫前期患者及正常产妇的血清抗心磷脂抗体及抗β 2-GPI抗体的滴度值,并详细记录研究组及对照组的妊娠结局.结果三组产妇血清ACA-IgG、ACA-IgM和抗β 2-GPI抗体的滴度值差异有统计学意义（P＜0.05）.研究Ⅱ组的ACA-IgG抗体滴度值较对照组升高,研究Ⅱ组的ACA-IgM抗体滴度值较对照组及研究Ⅰ组升高,研究Ⅰ组的抗β 2-GPI抗体滴度值较正常组显著升高,差异有统计学意义（P＜0.05）.三组孕妇发生FGR、早产、围生儿死亡、胎盘早剥、死胎的机率比较,研究Ⅱ组高于研究Ⅰ组,研究Ⅰ组高于正常对照组,差异有统计学意义（P＜0.05）.ACA-IgM与胎儿生长受限呈正相关,ACA-IgG、ACA-IgM及抗β 2-GPI抗体与早产具有显著性相关,抗β 2-GPI抗体与围生儿死亡具有相关性,ACA-IgG、ACA-IgM与抗β 2-GPI抗体三者之间两两均存在显著的相关性.结论母血ACA-IgG、ACA-IgM、抗β 2-GPI抗体的滴度值与子痫前期患者的不良妊娠结局的发生具有一定的相关性,且呈正相关.

作者郭丽娟

机构地区枣庄市妇幼保健院高危产科

出处《国际医药卫生导报》 2015年第12期1671-1674,共4页 International Medicine and Health Guidance News

关键词妊娠高血压抗心磷脂抗体抗β2-GPI抗体相关性

分类号 R714 [医药卫生—妇产科学]

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参考文献15

1Genbacev O,Joslin H,Damsky CH,et al.Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsia[J].J ClinInvest,1996,97(2):540-550.
2Genbacev O,Zhou Y,Ludlow JW,et al.Regulation of human placental development by oxygen tension[J].Science,1997,277(5332):1669-1672.
3Sammaritano LR,Lockshin MD,Gharavi AE.Antiphospholipid antibodies differ in aPL cofactor requirement[J].Lupus,1992,1(2):83-90.
4Harris EN,Gharavi AE,Boey ML,et al.Antioardiolipin antibodies:detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus[J].Lancet,1983,2(8361):1211-1214.
5Miyakis S,Giannakopoulos B,Krilis SA.Beta 2 glycoprotein I--function in health and disease[J].Thromh Res,2004,114(5-6):335-346.
6杨孜,林其德.子痫前期-子痫的病理生理学研究[J].中华妇产科杂志,2006,41(8):507-508. 被引量：27
7卢柳娟.早发型重度子痫前期82例临床分析[J].国际医药卫生导报,2013,19(6):816-818. 被引量：8
8邢建琴,郭兆荣,王忠叶.溶血磷脂酸与抗心磷脂抗体联合检测在妊高症患者中的临床意义[J].国际医药卫生导报,2014,20(16):2493-2496. 被引量：4
9黎燕,韩志萍,王芳,苏放明.早发型重度子痫前期母血中抗磷脂抗体及血栓前状态变化的研究[J].中华临床医师杂志（电子版）,2013,7(18):108-112. 被引量：14
10BarJ,Cohen-Sacher B,Hod M,et al.Low-molecular-weight heparin for thrombophilia in pregnant women[J].Int J Gynaecol Obstet,2000,69(3):209-213.

二级参考文献25

1Blum A,Shenhav M,Baruch R,et al.Endothelial dysfunction in preeclampsia and eclampsia:current etiology and future non-invasive assessment.Isr Med Assoc J,2003,5:736-738.
2Azizieh F,Raghupathy R,Makhseed M.Maternal cytokine production patterns in women with pre-eclampsia.Am J Reprod Immunol,2005,54:30-37.
3Pang ZJ,Xing FQ.Comparative study on the expression of cytokine:receptor genes in normal and preeclamptic human placentas using DNA microarrays.J Perinat Med,2003,31:153-162.
4Lee H,Park H,Kim YJ,et al.Expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in human preeclamptic placenta:possible implications in the process of trophoblast apoptosis.Placenta,2005,26:226-233.
5Mutter WP, Karumanchi SA, Mechanisms of pre-eclamp- sia [J]. Microvasc Res, 2008, 75 (1) : 1.
6Stanhope TJ,White WM,Moder KG. Obstetric nephrology:lupus and lupus nephritis in pregnancy[J].Clin J Am Soc Nephrol,2012.2089-2099.
7Branch DW,Silver RM,Blackwell JL. Outcome of treated pregnancies in women with antiphospholipid syndrome:an update of the Utah experience[J].Obstetrics and Gynecology,1992.614-620.
8Ruffatti A,Tonello M,Cavazzana A. Laboratory classification categories and pregnancy outcome in patients with primary antiphospholipid syndrome prescribed antithrombotic therapy[J].Thrombosis Research,2009.482-487.
9Dreyfus M,Hedelin G,Kutnahorsky R. Antiphospholipid antibodies and preeclampsia:a case-control study[J].Obstetrics and Gynecology,2001.29-34.
10Branch DW,Porter TF,Rittenhouse L. Antiphospholipid antibodies in women at risk for preeclampsia[J].American Journal of Obstetrics and Gynecology,2001.825-834.