凝血酶联合冰冻盐水膀胱灌注治疗膀胱癌TURBT术后难治性血尿临床观察

Clinical observation of thrombin combined with frozen normal saline bladder irrigation in refractory hematuria of patients with bladder cancer after TURBT

目的 探讨凝血酶联合冰冻生理盐水膀胱灌注对膀胱癌TURBT术后难治性血尿临床疗效的影响.方法 选取本院特定时间段住院的符合标准的膀胱癌TURBT术后难治性血尿患者19例,以治疗前症状、尿常规等情况作为对照组,均予凝血酶联合冰冻生理盐水膀胱灌注干预后,对其症状、尿常规等重新进行评估作为治疗组,对比治疗前后的差异.结果 临床观察结果显示,与治疗前比较,19例疗效较满意,血尿症状消失,尿常规示红细胞（-～＋）,其中5例灌注1次后出血停止,症状明显缓解;8例灌注少于4次后,出血停止,病情稳定后出院;5例灌注7次,同时给予止血对症支持治疗后,病情缓解.结论 凝血酶联合冰冻生理盐水膀胱灌注膀胱癌TURBT术后性血尿止血疗效明显,简单易行,且经济实惠,缩短了患者术后恢复正常排尿时间.

Objective To investigate clinical efficacy of thrombin combined with frozen normal saline bladder irrigation in refractory hematuria of patients with bladder cancer after TURBT.Methods 19 cases of bladder cancer combined with refractory hematuria after TURBT in our hospital from February 2013 to February 2015 were selected,all patients received thrombin combined with frozen normal saline bladder irrigation treatment,recorded their clinical symptoms and routine urine examination results before and after treatment.Results Curative effect of 19 patients was satisfactory,hematuria symptoms disappeared,routine urine examination showed red blood cells （-～ ＋）.Bleeding stopped in 5 cases after 1 time of bladder irrigation,symptoms relieved;bleeding stopped in 8 cases after less than 4 times of bladder irrigation,discharged in stable condition;5 cases received 7 times of bladder irrigation and hemostasis symptomatic and supportive treatment,condition relieved.Conclusions Thrombin combined with frozen normal saline bladder irrigation has obvious hemostatic effect in refractory hematuria of patients with bladder cancer after TURBT,simple and affordable,which shortens time of urination returning to normal of patients.