益心泰颗粒对慢性心衰兔血清AngⅡ、ALD及BNP的影响

Impact of Yixintai on AngⅡ, ALD and BNP in Serum of Rabbit with Chronic Heart Failure

目的:探讨益心泰颗粒对慢性心衰兔血清血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)及脑钠肽(BNP)的影响。方法:用阿霉素耳缘静脉注射建立慢性心衰兔模型,将造模成功的新西兰兔分为模型组、益心泰低、中、高剂量组和呋塞米组;另设正常对照组。灌胃4周,实验结束后检测血清AngⅡ、ALD及BNP的浓度值。结果:与模型组比较,益心泰高、中、低剂量组血清AngⅡ、ALD及BNP浓度值均显著降低(P<0.01),且益心泰中、高剂量组优于益心泰低量组。结论:益心泰颗粒可以明显降低慢性心衰兔血清AngⅡ、ALD及BNP浓度值,且中、高剂量组疗效优于低剂量组。

Objective： To explore the impact of Yixintai （益心泰） on Ang Ⅱ, ALD and BNP in serum of rabbit with chronic heart failure（CHF）. Methods： The rabbit model of CHF was established with adriamycin. These successful CHF models of rabbits were divided into model group, high, middle and low dose of Yixintai group and Furosemide group, plus the normal control group. The levels of Ang Ⅱ, ALD and BNP in serum were measured after 4 weeks of medication. Results： Compared with the model group, the levels of AngⅡ, ALD and BNP in serum were significantly lower（P〈0.01）, and the middleand high groups were both superior to the low dose group. Conclusion： Yixintai can reduce the levels of Ang Ⅱ, ALD and BNP in serum of patients with CHF, and the middleand high groups were both superior to the low dose group.