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中药调节肾脏纤维化ERK信号通路研究进展 被引量：2

Research Progress of Effect of Chinese Medicine on ERK Pathway in Renal Fibrosis
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摘要 阐述了ERK信号通路的生物学特征及信号转导机制,总结了ERK信号通路与肾脏纤维化以及中药对肾脏纤维化ERK信号通路的影响,认为一些中药及复方可以通过细胞外信号调节激酶调控相关细胞因子的分泌,抑制系膜细胞增生和细胞外基质分泌,从而改善肾脏纤维化。 This paper summarizes the biological characteristics of the ERK pathway as well as the signal transduction mechanism, the ERK pathway, renal fibrosis and the influence of Traditional Chinese Medicine on ERK pathway of renal fi- brosis; Some Traditional Chinese Medicine and compound can regulate kinase, control secretion of related cytokine, and inhibit mesangial cell proliferation and extracellular matrix secretion, through the extracellular signal, in order to improve renal fibrosis.
作者 胡浩 孙伟 涂玥 刘红
机构地区 南京中医药大学 江苏省中医院
出处 《中医药导报》 2015年第13期96-98,共3页 Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金 国家自然科学基金面上项目(No.81373607) 江苏省高校优势学科建设工程资助(JD11049)
关键词 中药 ERK信号通路 肾脏纤维化 Chinese Medicine ERK pathway Renal fibrosis
分类号 R256.5 [医药卫生—中医内科学]
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参考文献18

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  • 2Krishna M, Narang H. The complexity of mitogen-acti- vated protein kinases (MAPKs) made simple[J]. Cell Mol Life Sci, 2008,65(22) : 3525-3544.
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  • 8Pat B, Yang T, Kong C, et al. Activation of ERK in renal fibrosis after unilateral ureteral obstruction: modu- lation by antioxidants[J]. Kidney Int,2005,67(3):931-943.
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中医药导报
2015年 第13期

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