高危型HPV感染与宫颈癌癌前病变的相关性分析

Analysis of the Correlation Between High-risk HPV Infection and Cervical Precancerosis

目的探讨高危型人乳头瘤病毒(HR-HPV)感染与宫颈癌癌前病变的相关性。方法选取2011年1月—2013年6月该院收治的437例患者为研究对象,其中宫颈上皮内瘤样病变(CIN)CIN I 182例,CIN II 92例,CIN III 163例为病例组,同期来该院进行健康体检的健康妇女200例为对照组,对两组的HR-HPV亚型进行检测,并用条件多因素logistic回归分析HPV各型别与宫颈病变发病的危险度。结果 CIN I,CINII,CINIII的HPV阳性率均明显高于正常宫颈HPV阳性率,差异有统计学意义(χ2=53.45;91.75;93.50,P<0.01),并且随着癌前病变程度的加深HPVl6和HPV18的阳性率和OR值不断增加。结论 HPVl6感染与HPV18宫颈癌癌前病变密切相关。

Objective To investigate the correlation between high-risk HPV （HR-HPV） infection and cervical precancerosis. Methods 473 cases admibbed to this hospital from Jan 2011 to Jun 2013 were selected as the Subjects. 182 cases with cervical intraepithelial neoplasia （（;IN） I, 92 cases with CIN II and 163 cases with CIN III were selected as the case group, and 200 healthy women underwent health examination in our hospital during the same period were selected as the control group. The HR- HPV subtypes were detected in the two groups. And a multivariate logistic regression method was used to analyze the correlation between HR-HPV subtypes and the risk of incidence of cervical lesion. Results The positive rate of CIN Ⅰ, CIN Ⅱ, CIN Ⅲ patients was significantly higher than that of the normal group, respectively, the difference was statistically significant （x^2=53.45; 91.75; 93.50; all P〈0.01）. And with the cervical precancerosis deepening, the positive rate of HPVI6 and HPV18 and the OR value increased gradually. Conclusion HPVI6 and HPV18 infection are closely correlated with the severity of cervical precancerosis.