化学治疗栓塞术联合三维适形放射治疗原发性肝癌60例近期疗效观察

Analysis of Short-term Effects of Three-dimensional Conformal Radiotherapy with Chemoembolization for Hepatic Carcinoma

目的观察肝动脉化学治疗栓塞术(TACE)联合三维适形放射治疗(3D-CRT)用于原发性肝癌的近期疗效。方法对60例原发性肝癌患者实行TACE治疗;3周后实行3D-CRT治疗,平均48 Gy;然后再实行2次TACE治疗,治疗间隔4周。结果病情完全缓解者占20%(12/60),部分缓解者占38.3%(23/60),总有效率为58.3%(35/60);病情稳定者占35%(21/60);病情进展者占6.7%(4/60)。结论 TACE联合3D-CRT治疗原发性肝癌能够提高局部控制率,近期疗效好。

Objective To evaluate the short-term effects of three-dimensional conformal radiotherapy（3D-CRT） associated with transcatheter arterial chemoembolization（ TACE） treating the primary hepatic carcinoma. Methods All the 60 primary hepatic carcinoma patients were conducted by TACE treatment. After an interval of 3 weeks,the conformal radiotherapy was given with mean radiation dose,48 Gy. Afterwards,2 additional TACEs were given after radiotherapy. Results The shortterm effects were as follow：complete remission（ CR） 20%（12 /60）,partial remission（ PR） 38. 3%（23 /60）,stable disease（ SD） 35%（21 /60） and progressive disease（ PD） 6. 7%（4 /60）. Conclusion 3D-CRT with TACE can elevate local control rates and good short-term effects of hepatic carcinoma.