溶血葡萄球菌的临床分布特点及耐药性分析

Drug resistance and elinical distribution of Staphylococcus haemolyticus

目的了解溶血葡萄球菌的耐药性,为临床合理用药作出指导。方法从患者标本中分离出59株溶血葡萄球菌,并对其进行临床分布及耐药性分析。结果 59株溶血葡萄球菌主要集中于儿科与ICU等科室,标本主要来源于痰液和咽拭子,患者以新生儿为主;溶血葡萄球菌以耐甲氧西林溶血葡萄球菌(MRSH)为主,共53株,占89.8%;耐甲氧西林溶血葡萄球菌(MRSH)对多种抗菌药物呈高度多重耐药,而对万古霉素、替考拉宁、利奈唑胺敏感率高,为100.0%。结论溶血葡萄球菌是临床感染的重要的凝固酶阴性葡萄球菌之一,其以MRSH为主,且呈高度多重耐药,临床上应根据其药敏试验结果合理选用抗菌药物。

Objective To investigate the drug resistance of Staphylococcus haemolyticus and provide basis for selection of clini‐cal drugs .Methods A total of 59 strains of Staphylococcus haemolyticus were isolated from patients ,and analyzed the clinical dis‐tribution and drug resistance of them .Results Staphylococcus haemolyticus were mainly isolated from the sputum and oropharyn‐geal swabs in pediatric and ICU .The patients were mainly newborns .Staphylococcus haemolyticus mainly included methicillin re‐sistant Staphylococcus haemolyticus （MRSH） ,accounting for 89 .8% （53 strains） .MRSH showed high‐drug resistance and multi‐drug resistance .However ,it was sensitive to vancomycin ,teicoplanin and linezolid ,the antibiotic sensitive rate was 100 .0% .Conclu‐sion Staphylococcus haemolyticus is an important coagulase negative staphylococci ,mainly including MRSH ,which shows high‐drug resistance and multi‐drug resistance .