复治肺结核患者耐多药的影响因素分析

Research of factors influencing on the multi-drug resistant of recurrenttuberculosis patients

目的：探讨复治肺结核患者耐多药的影响因素。方法130例复治耐多药肺结核患者纳入研究组，110例复治非耐多药肺结核患者纳入对照组。比较2组患者年龄、性别、文化程度、结核病灶数、婚姻状况、体质量、第一次抗结核治疗持续时间、接受抗结核药治疗次数、病变累加肺野数、最近一次治疗结局等资料。结果2组患者年龄、文化程度、户籍、结核病灶数、病变累加肺野数、第一次抗结核治疗持续时间、接受抗结核药物治疗次数、最近一次抗结核治疗结局比较差异均有统计学意义（P＜0．05）。年龄（OR ＝1．160，95％ CI ：1．051～1．310）、文化程度（OR ＝3．142，95％ CI ：1．621～5．912）、户籍（OR ＝3．136，95％ CI ：1．617～5．827）、结核病灶个数（OR ＝2．989，95％ CI ：1．218～4．298）、最近一次治疗结局（OR ＝1．282，95％ CI ：1．019～2．296）、第一次抗结核治疗持续时间（OR ＝1．316，95％ CI ：1．216～1．579）、接受抗结核药物治疗次数（OR ＝1．361，95％ CI ：1．071～1．721）、病变累加肺野数（OR ＝1．796，95％ CI ：1．516～2．619）等因素和复治耐多药肺结核发病密切相关，是其主要影响因素。结论年龄、文化程度、结核病灶数、最近一次治疗结局、第一次抗结核治疗持续时间、接受抗结核药物治疗次数是复治耐多药肺结核发病的主要影响因素，对以上高危人群应做好肺结核耐多药的防治工作，以减少肺结核耐多药的发生率。

Objective To study factors influencing on the multi‐drug resistant of recurrent tuberculosis patients .Methods A to‐tal of 130 recurrent multi‐drug resistant tuberculosis patients were selected into study group ,and 110 recurrent tuberculosis patients without multi‐drug resistant were selected into control group .Data such as age ,gender ,educational level ,number of tuberculosis fo‐cus ,marital status ,weight ,anti‐tuberculosis treatment for the first time duration ,number of anti‐tuberculosis drug treatment ,lesion accumulation number of lung field ,the latest treatment outcome and so on in the two groups were compared retrospectively .Results Age ,culture level ,household registration ,the number of tuberculosis focus ,lesion accumulation number of lung field ,anti‐tuber‐culosis treatment for the first time duration ,number of anti‐tuberculosis drugs therapy ,a recent anti‐tuberculosis treatment outcome in the two groups were all significant different（P〈 0 .05） .Age （OR = 1 .160 ,95% CI ：1 .051 - 1 .310） ,education （OR = 3 .142 ,95%CI ：1 .621 - 5 .912） ,household registration （OR = 3 .136 ,95% CI ：1 .617 - 5 .827） ,the number of tuberculosis focus （OR = 2 .989 , 95% CI ：1 .218 - 4 .298） ,the latest treatment outcome （OR= 1 .282 ,95% CI ：1 .019 - 2 .296） ,the first anti‐tuberculosis treatment duration （OR = 1 .316 ,95% CI ：1 .216 - 1 .579） ,and treated with anti‐tuberculosis drugs number （OR = 1 .361 ,95% CI ：1 .071 -1 .721） ,the number of lesion accumulation lung field （OR = 1 .796 ,95% CI ：1 .516 - 2 .619） were closely related with the recurrent of multi‐drug resistant tuberculosis incidence ,as the main influencing factors .Conclusion Age ,culture level ,the number of tuber‐culosis focus ,the latest treatment outcome ,anti‐tuberculosis treatment duration for the first time ,treated with anti‐tuberculosis drugs number are main influencing factors of the recurrent of multi‐drug resistant tuberculosis .High‐risk groups should do a good job of prevention and control of multi‐drug resistant tuberculosis ,in order to reduce the incidence of multi‐drug resistant tuberculosis .