老年人消化性溃疡危险因素Meta分析及归因危险度百分比的探讨

Meta analysis on risk factors of peptic ulcer disease in the elderly and attributable risk percent

目的分析中国老年人消化性溃疡发病相关危险因素,为临床预防提供依据。方法收集国内2012-2014年公开发表关于老年人消化性溃疡发病危险因素的研究文献进行Meta分析及人群归因危险度百分比,查找老年人消化性溃疡发病危险因素。结果共纳入18篇文献,研究吸烟、饮酒、使用非甾体类药物及幽门螺杆菌感染等危险因素与老年人消化性溃疡之间的关系。其中吸烟、饮酒和非甾体类药物与老年人消化性溃疡相关,其OR（95%可信区间）分别为1.75（1.39-2.20）、1.6（1.33-1.93）及5.19（4.26-6.32）。结论吸烟、饮酒及非甾体类药物与老年人消化性溃疡相关,是老年人消化性溃疡的主要危险因素。

Objective To analyze the related risk factors of onset of peptic ulcer disease in the elderly, provide a basis for early clinical intervention. Methods The literatures related to risk factors of onset of peptic ulcer disease in the elderly published from 2012 to 2014 in China were collected, and then a Meta analysis was conducted, population attributable risk percent was calculated, the risk factors of onset of peptic ulcer disease in the elderly were analyzed. Results Eighteen studies were included in which the relationship between peptic ulcer disease in the elderly and risk factors such as Cigarette smoking status, Drinking, NSAIDs, Helicobacter pylori infection and Survival pressure. The results of Meta-analysis indicated that peptic ulcer disease in the elderly had close relationship with Cigarette smoking status, Drinking and NSAIDs. Their pooled OR and 95% CI were 1.75（1.39-2.20）, 1.6（1.33-1.93） and 5.19（4.26-6.32）, respectively. Conclusion Smoking, drinking and NSAIDs have close relationship with peptic ulcer disease in the elderly, and they are risk factors in pathogenesis of peptic ulcer disease in the elderly.