黄芪注射液治疗重症肺炎心衰患儿的疗效观察

Effect of Astragalus Injection on Treatment of Children with Severe Pneumonia Complicated Heart Failure

目的观察黄芪注射液治疗小儿重症肺炎并心力衰竭的疗效及治疗前后脑利钠钛(BNP)、心肌肌钙蛋白(c Tn I)的变化。方法将重症肺炎并心衰的患儿86例随机分为观察组和对照组各43例。对照组患儿按常规给予镇静、吸氧、抗感染、强心利尿等治疗,观察组在常规治疗的基础上加用黄芪注射液静脉滴注,7 d为1个疗程。治疗前后分别测定BNP、c Tn I的变化,并在治疗第3天进行疗效判定。结果两组患儿治疗后BNP、c Tn I水平均有下降(P<0.05),且观察组下降更明显(P<0.05);观察组显效率及总有效率均高于对照组(P<0.05)。结论黄芪注射液可改善心功能,对重症肺炎并心力衰竭有良好疗效。

Objective To investigate the effect of astragalus injuection on treatment of children with severe pneumonia with heart failure, and detect brain natriuretic peptide（BNP）, cardiac troponin I（c Tn I） before and after using of astragalus injuection. Methods 86 patients of severe pneumonia with heart failure were randomly divided into treatment group and control group 43 cases in each group. The control group＇s children were given sedation, oxygen, antibiotics, cardiac diuretic therapy. And the treatment group was given astragalus injection for 7 days on the basis of control therapy. The changes of BNP and c Tn I were measured before and after treatment. Results The results showed that the BNP and c Tn I were lower after therapy in two groups（P〈0.05）. The levels in the observation group were decreased more significantly than the control group.The significant efficiency and total efficiency of the observation group was significantly higher than the control group（P〈0.05）.Conclusion Astragalus injection can improve heart function and have beneficial therapeutic effect on children＇s severe pneumonia with heart failure.