中药细胞内作用靶点——线粒体

Intracellular Targets of Chinese Materia Medica: Mitochondria

多靶点、多途径整体治疗是中医药综合优势的特点所在,但机制尚不是十分清晰。本文通过分析中药药性、功效和针灸对线粒体作用,即中医药能够改善线粒体形态和结构,参与调节线粒体内能量代谢、抑制细胞凋亡、抵抗氧自由基等一系列代谢过程。结果显示中医药细胞内药物作用靶点与线粒体具有一定相关性。

Traditional Chinese medicine （TCM） has its advantages in a combination of multi-target and multi- channel overall treatment. However, its mechanism is still unclear. This article elaborated upon prior research results by analyzing the effect of property, efficacy of Chinese materia medica （CMM）, acupuncture and moxibustion on mitochondria. TCM can improve the morphology and structure of mitochondria. It was involved in a series of metabolic processes, which included the energy metabolism regulation, inhibition of cell apoptosis, and resistance of oxygen free radicals in mitochondria. The results showed that there existed a certain correlation between intracellular targets of TCM and mitochondria.