低分子肝素联合硫酸镁治疗早发型子痫前期的效果分析

Effect analysis of low molecular weight heparin combined with magne-sium in treatment of early-onset preeclampsia

目的探讨低分子肝素联合硫酸镁治疗早发型子痫前期的效果。方法选取2012年1月-2014年1月本院收治的早发型子痫前期患者56例,将其随机分为观察组和对照组,各28例。对照组采用硫酸镁进行治疗,观察组在对照组治疗的基础上给予低分子肝素进行治疗。比较两组治疗前后的血小板（PLT）计数、凝血酶原时间（PT）、凝血酶时间（TT）、部分凝血活酶时间（APTT）、纤维蛋白原（FIB）及D-二聚体的变化,记录两组孕产妇的产后出血情况。结果治疗前,两组的PLT计数、PT、TT、APTT、FIB及D-二聚体比较,差异无统计学意义（P〉0.05）;治疗后,两组的PLT计数差异无统计学意义（P〉0.05）,观察组的PT、TT、APTT较对照组延长,FIB及D-二聚体较对照组减少,差异有统计学意义（P〈0.05）。观察组的产后出血量为（327.4±78.2）ml,对照组为（274.6±86.7）ml,两组的产后出血量差异无统计学意义（P〉0.05）。结论低分子肝素联合硫酸镁治疗早发型子痫前期患者可明显改善患者的高凝状态,且不会增加出血风险。

Objective To investigate the effect of low molecular weight heparin combined with magnesium in treatment of early-onset preeclampsia. Methods 56 patients with early-onset preeclampsia treated in our hospital from January 2012 to January 2014 were selected,and they were randomly divided into observation group and control group,there were 28 cases in each group.Control group was treated with magnesium,while observation group was treated with low molecular weight heparin on the basis of control group.Platelet （PLT） count,prothrombin time （PT）,thrombin time （TT）, activated partial thromboplastin time （APTT）,fibrinogen （FIB） and D-dimer of two groups before and after treatment was compared,postpartum hemorrhage was recorded. Results Before treatment,PLT count,PT,TT,APTT,FIB and D-dimer of two groups had no significant difference （P〉0.05）;after treatment,PLT count between two groups had no significant dif-ference （P〉0.05）,PT,TT,APTT of observation group was longer than that of control group respectively,FIB and D-dimer was decreased compared with that of control group,the difference was significant （P〈0.05）. Postpartum hemorrhage of the observation group was （327.4±78.2） ml,the postpartum hemorrhage of the control group was （274.6±86.7） ml,two groups had no significant difference （P〉0.05）. Conclusion Low molecular weight heparin and magnesium in treatment of patients with early-onset preeclampsia can significantly improve the hypercoagulable state in patients,and does not increase the risk of bleeding.