帕罗西汀对脑卒中后抑郁患者抑郁状态及神经功能恢复的影响

Impact of paroxetine on depression state and neurologic function recovery in patients with post-stroke depression

目的探讨帕罗西汀对脑卒中后抑郁患者抑郁状态及神经功能恢复的影响。方法选择2012年5月-2014年5月在本院就诊的脑卒中抑郁患者90例,将其随机分为对照组、治疗组,每组45例。对照组给予多虑平治疗,治疗组给予帕罗西汀治疗。比较两组治疗前后神经功能缺损评分的降低幅度、治疗效果、心理状态恢复正常时间、临床治疗总时间、药物不良反应发生率等。结果治疗组患者治疗前后神经功能缺损评分的降低幅度明显大于对照组（P〈0.05）;治疗效果明显优于对照组（P〈0.05）;治疗组患者的心理状态恢复正常时间、临床治疗总时间均较对照组显著缩短（P〈0.05）,药物不良反应发生率较对照组低（P〈0.05）。结论帕罗西汀治疗脑卒中后抑郁的临床效果非常明显。

Objective To study the impact of paroxetine on depression state and neurologic function recovery in pa-tients with post-stroke depression. Methods 90 patients with post-stroke depression treated in our hospital from May 2012 to May 2014 were selected,and they were randomly divided into control group and treatment group,and there were 45 patients in each group.The control group was treated with doxepin while treatment group was treated with paroxetine. Reducing degree of the score of neurologic function impairment,the curative effect,the recovery time of psychological status,total time of clinical treatment and the incidence rate of adverse reaction of drug between two groups was com-pared respectively. Results The reducing degree of the score of neurologic function impairment in treatment group be-fore and after medication was significantly higher than that in control group （P〈0.05）;the curative effect of treatment group was significantly better than that in control group （P〈0.05）;recovery time of psychological status and total time of clinical treatment in treatment group were both significantly shorter than those in control group （P〈0.05）;the incidence rate of adverse reaction was lower than that in control group （P〈0.05）. Conclusion Paroxetine has a significantly clini-cal effect treating post-stroke depression.