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Circular RNAs remain peculiarly unclear in biogenesis and function 被引量:4

Circular RNAs remain peculiarly unclear in biogenesis and function
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摘要 The known complexity of eukaryotic transcriptomes has been greatly expanded due to the identification of a large family of circular RNAs in recent years [1-3]. As a special form of RNA compared to the "common" linear form, these molecules were first described in 1976, when it was discov- ered that several plant viroids were single-stranded and co- valently closed circular RNAs [4]. The known complexity of eukaryotic transcriptomes has been greatly expanded due to the identification of a large family of circular RNAs in recent years[1?3].As a special form of RNA compared to the"common"linear form,these molecules were first described in 1976,when it was discovered that several plant viroids were single-stranded and covalently closed circular RNAs[4].In a broad sense。
出处 《Science China(Life Sciences)》 SCIE CAS CSCD 2015年第6期616-618,共3页 中国科学(生命科学英文版)
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  • 1Salzman J, Gawad C, Wang PL, Lacayo N, Brown PO. Circular RNAs are the predominant transcript isoform from hundreds of hu- man genes in diverse cell types. PLoS One, 2012, 7:e30733.
  • 2Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature, 2013, 495:333-338.
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