摘要
Cilia and flagella are conserved organelles protruding from the surface of eukaryotic cells and are composed of a ciliary membrane,axoneme,and basal body.Cilia are widely distributed in protozoans and vertebrates;their main functions are to sense environmental cues and drive cells to move.Defective ciliary structure and function have been implicated in a spectrum of diseases called ciliopathies。
Cilia and flagella are conserved organelles protruding from the surface of eukaryotic cells and are composed of a ciliary membrane, axoneme, and basal body. Cilia are widely distributed in protozoans and vertebrates; their main functions are to sense environmental cues and drive cells to move. Defective ciliary structure and function have been implicated in a spectrum of diseases called ciliopathies, including polycystic kidney disease （PKD）, retinal degeneration, res-piratory disease, and sterility. The prevalence of ciliopathies in man is approximately 1：1000, with no commercially available drugs. Therefore, the study of cilia and the patho-genesis of ciliopathies have attracted great interest.
