复方甘草酸苷用于慢性乙型肝炎治疗的疗效和安全性

Efficacy and Safety of Compound Glycyrrhizin for the Treatment of Chronic Hepatitis B

目的探讨分析复方甘草酸苷用于慢性乙型肝炎治疗的疗效及安全性。方法依照治疗方法不同手段将2009年12月—2012年12月该院收治的72例慢性乙型肝炎患者均分为对照组与观察组,对照组36例患者采用基础的保肝治疗手段,其余的患者则纳入观察组,在对照组治疗的基础上辅以复方甘草酸苷注射液进行治疗,对比观察两者不同治疗手段的疗效及安全性。结果观察组的患者优良率高达83.33%,对照组则为63.89%,前者占优势,且不良反应少;在慢性乙型肝炎患者的降黄及降酶方面,观察组均优于对照组的治疗。结论复方甘草酸苷用于慢性乙型肝炎起到护肝、降酶、退黄及调节免疫等作用优于基础的护肝治疗手段,疗效好,且不良反应少。

Objective To summarize and analyze the efficacy and safety of Compound glycyrrhizin for the treatment of chronic hepatitis B. Methods Seventy-two cases with chronic hepatitis B admitted in this hospital from December 2009 to December 2012 were equally divided into the control group and the observation group in accordance with different treatment method. 36 cases in the control group were given the basic protecting liver treatment, and the other 36 cases in the observation group were given the Compound glycyrrhizin for injection based on the treatment given to the control group. And the efficacy and safety of the two groups were observed and compared. Results The excellent and good response rate of the observation group was 83.33%, higher than 63.89% of the control group; the observation group had less adverse reactions and better effect on eliminating jaundice and reducing the levels of hepatic enzymes. Conclusion For chronic hepatitis B, Compound glycyrrhizin has better effect than the basic protecting liver treatment in the aspects of protecting liver, reducing the levels of hepatic enzymes, eliminating the jaundice and regulating the immunization with less adverse reactions.