奥沙利铂联合多西他赛治疗晚期复发食管癌临床分析

Clinical analysis of oxaliplatin combined with docetaxel in the treatment of late recurrence of esophageal cancer

目的分析和探讨应用奥沙利铂联合多西他赛对晚期复发食管鳞状细胞癌的疗效。方法选取该院2007年3月—2013年12月收治的32例晚期复发食管鳞状细胞癌患者,对其临床治疗资料进行回顾性分析。结果观察组患者在近期临床总有效率68.75%、远期存活率以及不良反应率方面均明显优于对照组患者(31.25%),组间比较存在显著性差异有统计学意义(P<0.05)。结论采用奥沙利铂联合多西他赛对晚期复治食管鳞状细胞癌患者进行治疗,其临床疗有效率较高,不良反应可以耐受,是一种安全有效的临床治疗措施。

Objective To analyze the effects and explore the application of oxaliplatin combined with docetaxel on advanced and recurrent esophageal squamous cell carcinoma. Methods 32 cases of 2007 March to 2013 December were treated in our hospital from late recurrence in patients with esophageal squamous cell carcinoma, clinical treatment data of them were retrospectively an-alyzed. Results The observation group patients in recent clinical total effective rate 68.75%, survival rate and adverse reaction rate were significantly better than the control group 31.25% patients, relatively significant difference between groups, with statistical significance （P〈0.05）. Conclusion With oxaliplatin combined with docetaxel on advanced retreatment of patients with esophageal squamous cell carcinoma, the clinical effective rate is high, with tolerable side effects, is a safe and effective clinical treatment measures.