黄芪结合标准三联疗法根除幽门螺杆菌的临床研究

Astragalus membranaceus combined with standard triple therapy the eradication of helicobacter pylori in clinical research

目的探究与分析黄芪结合标准三联疗法根除幽门螺杆菌的临床效果。方法选取该院自2012年10月—2014年10月收治的Hp感染阳性的的胃炎或消化性溃疡患者240例,采取随机数字表法分为A组、B组、C组、D组,每组各60例。A组给予泮托拉唑+阿莫西林+克拉霉素治疗。B组、C组、D组在A组基础上分别给予黄芪颗粒1g、2g、3g治疗。对比四组HP根除率及不良反应。结果 B组较A组相比,HP根除率明显提升(P<0.05),C组较A组相比,HP根除率明显提升(P<0.05),D组较A组相比,HP根除率明显提升(P<0.05),其中C组HP根除率提高程度明显高于B组,D组HP根除率提高程度明显高于C组。四组患者不良反应的发生率比较无明显差异(P>0.05)。结论黄芪结合标准三联疗法可达到更好的杀灭幽门螺杆菌的效果,不良反应较少,安全性高,值得推广。

objective to explore and analyze the root of remembranous milk vetch combined with standard triple therapy clinical effect of helicobacter pylori eradication. Methods select our hospital from October 2012 to October 2012 Hp infection were posi-tive in 240 cases of patients with gastritis and peptic ulcer, take A random number table method is divided into group A and group B, C, D group, each group of 60 cases each. A group was given diazepam tora azole, amoxicillin and clarithromycin treatment. Group B, C, D group on the basis of group A were given astragalus particles 1 g, 2 g, 3 g, treatment. Four groups of HP eradicate rate and adverse reactions. Results compared with group B than in group A, HP eradicate rate improved significantly （P 〈 0.05）, compared with group C compared with group A, HP eradicate rate improved significantly （P〈0.05）, group D is compared to group A, HP eradicate rate improved significantly （P〈0.05）, including HP eradicate rate of group C was significantly higher than that of group B, group D HP eradicate rate increase was significantly higher than that of group C. Four groups of patients the incidence of adverse reactions was no significant difference （P 〉 0.05）. Conclusion astragalus membranaceus combined with standard triple therapy can achieve better kill the effect of helicobacter pylori, less adverse reaction, high safety, is worth promoting.