氢吗啡酮治疗的临床应用及不良反应分析

Clinical application and adverse reaction of hydrogen morphine methadone treatment analysis

目的探讨氢吗啡酮治疗难治性神经病理性疼痛的疗效及不良反应分析。方法将2013年1月—2014年1月该院收治的60例难治性神经病理性疼痛患者随机分为对照组和观察组(各30例),观察组用氢吗啡酮治疗,对照组给予普瑞巴林,分析两组方案治疗4周后的疼痛缓解程度,睡眠情况并记录不良反应。结果观察组的疼痛总缓解率和明显缓解率均高于对照组(P<0.05)。对照组和观察组治疗后的睡眠干扰评分分别为(4.2±1.3)分和(2.8±0.8)分,低于对照组(P<0.05)。观察组不良反应少于对照组,差异有统计学意义(P<0.05)。结论氢吗啡酮治疗难治性神经病理性疼痛的疗效较好,不良反应少,可在临床进行推广。

Objective To study the hydrogen morphine methadone treatment intractable neurological pain rational analysis of the curative effect and adverse reactions. Methods 60 patients with refractory neuropathy pain were randomly divided into control group and observation group （30 cases）, the observation group was treated with hydrogen morphine ketone, the control group given pregabalin, analysis of two groups of patients with the degree of pain relief after 4 weeks, sleep and record adverse reactions. Re-sults The observation group the total remission rate and obvious pain relief rate are higher than the control group （P 〈 0.05）. Con-trol group and observation group after treatment of sleep disturbance scores, respectively （4.2±1.3） and （2.8±0.8）, lower than the control group （P 〈 0.05）. Observation group, adverse reaction is less than the control group with statistical significance （P 〈 0.05）. Conclusion Morphine hydrogen methadone treatment the curative effect of refractory mental derangement pain is good, less ad-verse reaction, can be popularization in clinical.